17 Aromatic Phosphate Plasticizers | Toxicological Risks

                                               
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17 Aromatic Phosphate Plasticizers - National Center

                                               
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Databook of Plasticizers - 2nd Edition

                                               
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Santicizer Phosphate Ester Flame Retardant Plasticizers

                                               
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Phosphate esters - Plasticisers - Information Center

                                               
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  • Is tricresyl phosphate a flame retardant?
  • The subcommittee also identified data gaps and recommended research relevant for determining the health risk from exposure to TCP. Tricresyl phosphate (TCP) is one of several aromatic phosphate esters used commercially as a flame retardant. The physical and chemical properties of TCP are summarized in Table 17–1.
  • What is tricresyl phosphate (TCP)?
  • THIS chapter reviews the physical and chemical properties, toxicokinetics, toxicological, epidemiological, and exposure data on tricresyl phosphate (TCP), an aromatic phosphate ester. TCP is one of several aromatic phosphate esters used commercially as flame retardants and plasticizers.
  • Can phosphate plasticizers reduce fire hazard?
  • It is found that for the materials based on epoxy oligomers and synthetic rubbers, no phosphate plasticizers can be practically used for the reduction of the fire hazard; such plasticizers only increase the flammability of PMC.
  • Do aromatic phosphate esters have a dermal RfD for TCP?
  • Quantitative toxicity assessments of aromatic phosphate esters was estimated using toxicity data for TCP. Therefore, these assessments will be overly conservative for the toxicity of other aromatic phosphate esters. No studies were identified that could be used to derive a dermal RfD for TCP.
  • Does cyclic phosphate cause neurotoxicity?
  • However, it is possible that cyclic phosphate could be formed from the metabolism of mixed, ortho-cresol-containing TCP isomers and produce neurotoxic effects if these isomers are present. No studies were identified that evaluated the reproductive and developmental effects of TCP in humans.