Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D
The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches.
3D Printing Plasticizer-Free Hydrophilic Matrices for Drug Delivery
Geometrical and morphological characteristics of 3D printed hydrophilic matrices (n = 5, standard deviations are in parenthesis). “… it can be concluded that the viscosity of HPMC has a...
Matrix systems for oral drug delivery: Formulations and drug release
Hydrophilic matrix tablets consist of at least three components: active ingredient, one or more matrix forming agent and tablet excipients. In this case the matrix forming agents are swellable or, in certain cases, soluble polymers ( Table 3) which will regulate the drug dissolution in the body.
Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D
The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded laments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches.
Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D
Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies June 2025 DOI: Authors: Zara...
- Can 3D printed hydrophilic matrices be plasticizer-free?
- The aim of the current project wasto develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches.
- How hard are 3D printed hydrophilic matrices?
- Measured breaking force measurements for 3D printed hydrophilic matrices exceeded the accepted range [85.2–93.8 N (8.7–9.6 kg)] for solid tablets [ 9 ]. The 3D printing process does not involve compression forces so it is obvious that this parameter does not exist to manipulate the hardness of 3D printed tablets.
- Do glipizide loaded filaments produce 3D printed hydrophilic matrices?
- All the glipizide loaded filaments produced 3D printed hydrophilic matrices, characterised as detailed in Table 4. There were no statistically significant differences in thickness, diameter and weight.
- Do 3D printed matrix tablets have a diffusion-controlled mechanism?
- The R 2 values displayed in the table (0.97-0.99) indicate that the data was well described by the Vergnaud mathematical model and, as an n value <0.5 is indicative of a diffusion-controlled mechanism, it can be deduced that swelling by the 3D printed matrix tablets follows a diffusion-controlled mechanism.
- Does polymer swelling control drug release from hydrophilic matrices?
- Polymer swelling is an important property in controlling drug release from hydrophilic matrices [ 51 ]. Figure 7 displays the swelling profiles of all types of 3D printed HPMC based glipizide matrices with respect to time.
- What are hydrophilic polymers used for?
- Polymers (Basel). 2019 Jul; 11 (7): 1095. Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for thedevelopment of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion.
