Di(2-ethylhexyl) adipate plasticizer triggers hepatic

                                               
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Di(2-ethylhexyl) adipate plasticizer triggers hepatic, brain

                                               
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Plasticizers May Activate Human Hepatic Peroxisome

                                               
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Phthalate and novel plasticizer concentrations in food items

                                               
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Di(2-ethylhexyl) adipate - Some Industrial Chemicals - NCBI

                                               
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  • Is di (2-ethylhexyl) adipate a plasticizer?
  • Di (2-ethylhexyl) adipate (DEHA) is a widely used plasticizer and prevalent environmental contaminant. In this study, DEHA concentrations in the milk, cheese, and butter samples wrapped with food-grade commercial polyethylene films and stored at 4 °C for 30 days were detected using gas chromatographic analysis.
  • What is Di 2 ethylhexyl adipate (DeHa)?
  • Di (2-ethylhexyl) adipate or bis (2-ethylhexyl) adipate (DEHA) is a potential plasticizer that markedly enhances polymeric product flexibility (Xu et al., 2019). It is incorporated in the manufacturing of many products like flooring, wall coverings, paints, lacquers, toys, artificial leather, and medical devices (Malarvannan et al., 2019).
  • How does DEHA exposure affect hepatic CYP2E1 and CYP2E1 immunolabeling?
  • Besides, a significant downregulation in hepatic CYP2E1, brain glial fibrillary acidic protein, and cardiac troponin I gene expression was noticed. Moreover, DEHA exposure induced a significant decrease in Bcl-2 immunolabeling, but Caspase-3 immunoexpression was increased.
  • Do plasticizers cause hyperglycemic conditions?
  • A similar hyperglycemic condition has been reported with other plasticizers like DEHP (Lin et al., 2011, Venturelli et al., 2015). This effect has been linked to the reduction of insulin secretion due to diminished insulin signaling molecules expression with subsequently reduced glucose uptake (Lin et al., 2011).