Pharmaceutical Tablet Film Coatings | PharmaCentral
The polymer is the film former and the main component on the formulation. The ideal polymer is one capable of producing smooth, thin films that are reproducible under routine coating conditions. The range of materials that can be used as film formers is very wide and covers materials that may be natural, synthetic or semi-synthetic.
Effects of plasticizers and surfactants on the film forming
Uniformity in tablet weight gain and thickness of the film coat data obtained from cast film measurements are supportive for elegant film formation. The quality of aqueous film coat or the plasticizer efficiency in case of PEG-400 is in the order 1.5 > 0.5 > 1.0% and for PG 1 > 4 > 3%. This preliminary study infers that plasticizer
Thin-film drug delivery
Film obtained should be tough enough so that there won't be any damage while handling or during transportation. Combination of microcrystalline cellulose and maltodextrin has been used to formulate Oral Strips of piroxicam made by hot melt extrusion technique.
Pharmaceutical Applications of Plasticized Polymers - IntechOpen
2.1.1 Film formation facilitated by plasticizer The film-formation mechanism from the coating dispersions is a complex process influenced mainly with the type and also with the quantity of plasticizer. The temperature below which a coating will not form a continuous, cohesive film is called the minimum film forming temperature; it is the
Effects of plasticizers and surfactants on the film forming
Hydroxy propyl methyl cellulose (HPMC) 5cPs, an aqueous soluble polymer was employed for coating diclofenac sodium (DFS) tablets 25 mg for protecting the integrity of the drug yet rendering the...
- Which film forming formulation is best for tablet coating?
- 4. Executive summary In conclusion, tablet coating films made of HPMC 5cPs with the addition of PEG at 1.5% and SLS at 0.3% and films made of HPMC 5cPs with PG at 1% and Tween-80 at 0.3% could be considered as an elegant film forming formulation for solving different coating problems generally faced in an industrial scale.
- What plasticizers are used in film coating?
- This reaction results in increased film flexibility and reduced residual stresses within the coating as it shrinks around the core during drying. Examples of plasticizers commonly used in film coating processes include: Polyols, such as glycerol (glycerin), polyethylene glycols (PEG 200 – 6000 grades) and propylene glycol.
- Is HPMC a film forming polymer?
- HPMC and HPC are two of the polymers most frequently used as film formers in commercial ODFs. In the case of HPMC, its film-forming properties have been well investigated due to its wide use as a film-coating polymer for tablets and granules.
- How do plasticizers affect film coating?
- Film coating is a complex process that involves different factors. To ensure spreading and/or film forming capability plasticizers are added. The type and concentration of plasticizers can affect the film properties, as revealed by several investigations ( Mortada, 1990, Siepmann et al., 2005, James, 1997 ).
- What is modified-release film coating?
- Modified-release (or functional) film coatings are used when drug release characteristics need to be modified. Modified-release film coatings may be further categorized as either delayed-release (e.g. gastro-resistant/ enteric coating) or extended-release coatings.
- What polymers are used to make film?
- Thus far, the films have been made from the following polymers: starch, hydroxypropylmethyl cellulose (HPMC) [, , , , ], hydroxypropyl cellulose (HPC) [, , ], sodium alginate, pectin, CMC , pullulan [, , ], povidone polymers (polyvinylpirollidone) , maltodextrins and others .
