DEHT is a suitable plasticizer option for phthalate-free
Of the four combinations, membrane stability was least impacted in DEHP/PAGGSM. Conclusion: We demonstrate that DEHT is a suitable plasticizer for storage of RBCs after X-ray irradiation cell stress. This strengthens the option of DEHT as a viable non-phthalate substitute for DEHP.
Analytical methods for the determination of DEHP plasticizer
It was also successfully used by Rothenbacher et al. [50] to determine if a rapid screening test for plasticizers (like DEHP, DINP, or DINCH) in PVC materials can be developed using direct analysis in real time mass spectrometry (DART-MS). An open interface would allow the direct insertion of solid specimens, such as samples of medical devices.
Bio-Based Plasticizers for Polyvinylchloride (PVC) | SpringerLink
Among phthalate esters, di- (2-ethylhexyl) phthalate (DEHP) is the widely used plasticizer in order to give the necessary flexibility for PVC compounds from medical devices such as medical tubing and blood bags [ 7, 8 ], to footwear, electrical cables, packaging, and flooring.
The Effect of Formulation Excipients on Leachables for IV
In-use stability studies typically evaluate compatibility of the admixture with the diluent (e.g., normal saline or 5% dextrose solution) and fluid-path contact material. The in-use study should be designed to evaluate the concentration ranges that provide the desired dose levels in the clinic.
Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP
10.1007/s00253-014-6183-8 Abstract Di(2-ethylhexyl)phthalate (DEHP) is a widely used plasticizer to render poly(vinyl chloride) (PVC) soft and malleable. Plasticized PVC is used in hospital equipment, food wrapping, and numerous other commercial and industrial products.
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- Which plasticizers are used in MDS?
- The review focuses on the aternative to DEHP plasticizers currently used in the MDs. Their migration from PVC depends partially on their physicochemical properties. The patient׳s exposure is the main risk and has to be investigated. Appropriate analytical methods are developed to quantify them in different matrices.
- Which plasticizer is the most stable?
- TOTM appears to be the most stable plasticizer in short-term and long-term thermal stability studies (Fig. 2) . Fig. 2. Weight loss of traditional plasticizers (including TOTM) and ionic liquids during long-term stability of 20 wt% plasticized samples at 100 °C (from Rahman et al. ).
- Is dehf a secondary plasticizer?
- An FTIR study revealed that at the relatively low contents of DEHF in the DEHF/DEHT plasticizer mixture (lower than 10/45 phr), it acted as a secondary plasticizer and dominated the interactions between PVC and DEHT.
- Which plasticizers can be used in a concentration range?
- The method developed by the authors can be applied to different types of plasticizers, like DINP or DEHP, within a concentration range of 10–50% by weight.
- Can plasticizers be quantified by GC–MS?
- Gimeno et al. recently published a new GC–MS technique to quantify 19 plasticizers in a single run. Among their tested compounds ATBC, DEHT, DINCH and TOTM were also analyzed. In their study, plasticizers were extracted by dissolving PVC samples in THF and precipitating with ethanol .
