Subacute exposure to di-isononyl phthalate alters the morphology
Di-isononyl phthalate (DiNP), a common plasticizer used in polyvinyl chloride products, exhibits endocrine-disrupting capabilities. It is also toxic to the brain, reproductive system, liver,...
Skin permeation and metabolism of di(2-ethylhexyl) phthalate (DEHP
Abstract. Phthalates are suspected to be endocrine disruptors. Di (2-ethylhexyl) phthalate (DEHP) is assumed to have low dermal absorption; however, previous in vitro skin permeation studies have shown large permeation differences. Our aims were to determine DEHP permeation parameters and assess extent of skin DEHP metabolism among workers
Chronic Hazard Advisory Panel Report on Diisononyl Phthalate (DINP)
Human exposure to DINP may occur via oral, dermal, and inhalation exposure routes. Based upon the physiochemical characteristics of DINP and limited monitoring data, general environmental exposure to DINP in the U.S. adult population is likely to be substantially lower than exposure to DEHP, which is estimated at 0.003-0.03 mg kg-1d-1
Analysis and Assessment of Exposure to Selected Phthalates Found
Diisononyl phthalate (DINP), di-n-octyl phthalate (DNOP) and diisodecyl phthalate (DIDP), on the other hand, are all noted to produce hepatotoxicity in the rat, through peroxisome proliferator receptor mechanisms that have questionable relevance to humans [8,9,11,17].
Diisononyl phthalate (DINP) Skin Absorption and Oral Exposure
11% of Diisononyl phthalate (DINP), CAS No. 28553-12-0, was reported in a sample of the plastic grip of a basting brush (TV SD Vietnam, 2025). Results for blank and DINP standard samples were very good. III. Exposure assessment Skin absorption was modeled based on guidance from OEHHA (2017).
- What is Di-isononyl phthalate (DINP)?
- Abstract Di-isononyl phthalate (DINP; CAS no. 68515-48-0) is a general-purpose plasticizer for polyvinyl chloride. It produced liver and kidney effects when given to rodents at high oral doses, but...
- What are high molecular-weight phthalates (DINP) and diisodecyl phthalate (D?
- High molecular-weight phthalates, such as diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP), are widely used as plasticizers in the manufacturing of polymers and consumer products. Human biological monitoring studies have employed the metabolites of DINP and DIDP as biomarkers to assess human exposure.
- Does diisononyl phthalate cause chronic toxicity?
- Babich MA. The Risk of Chronic Toxicity Associated with Exposure to Diisononyl Phthalate (DINP) in Children's Products. Bethesda, Md, USA: United States Consumer Product Safety Commission; 1998. [Google Scholar] 47. Babich MA, Chen SB, Greene MA, et al. Risk assessment of oral exposure to diisononyl phthalate from children’s products.
- What is Di-isononyl phthalate?
- Di-isononyl phthalate (DINP; CAS no. 68515-48-0) is a general-purpose plasticizer for polyvinyl chloride. It produced liver and kidney effects when given to rodents at high oral doses, but there were no target organ effects in primates treated under similar conditions.
- What is di-isononylphthalate (DINP)?
- Di-isononylphthalate (DINP) is the subject of the study titled 'Di-isononylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP' published in the International Journal of Hygiene and Environmental Health, 210:9–19.
- How does phthalate absorption affect dermal exposure?
- Dermal exposure to phthalates can get increased due to absorption via the hands and lips. Phthalate DINP is partially dissolved in saliva, which enhances the amount available for dermal absorption. Limited quantitative absorption data are available for DINP.
