Non-phthalate plasticizer DEHT preserves adequate blood
The metabolic parameters were not influenced by choice of plasticizer. Platelet activation/metabolism and plasma content were similarly preserved. Conclusion: Our study demonstrates that the plasticizer DEHT provides adequate blood component quality. We propose DEHT as a strong future candidate for replacement of DEHP in blood bags.
Diverging trends of plasticizers (phthalates and non-phthalates)
The plasticizer market changed in response to the restriction of low molecular weight (LMW) phthalate plasticizers such as Di (2-ethylhexyl) phthalate (DEHP) due to their hazardous properties. We investigated patterns and trends of 19 regulated and emerging plasticizers in house dust from German homes and in suspended particulate matter (SPM) from major German rivers.
DEHT is a suitable plasticizer option for phthalate-free storage
Di (2-ethylhexyl) terephthalate (DEHT) provides sufficient red blood cell (RBC) quality during conventional blood bank storage. It is important that a new plasticizer also maintains acceptable quality during exposure to high cell stress, such as irradiation, which is commonly used to prevent graft-versus-host disease.
Plasticizers: Types, Uses, Classification, Selection & Regulation
DEHP offers good gelling, satisfactory electrical properties and helps to produce highly elastic compounds with reasonable cold strength. It displays fairly good flexibility at low temperatures and some resistance to high-temperature. However, DEHP is listed by the IARC as a human carcinogen.
Non‐phthalate plasticizer DEHT preserves adequate blood component
Plasticizers are essential for material flexibility; facilitating centrifugation, sealing, transport and general handling of blood bags without risk of breakage and product loss . DEHP is a dipolar, lipophilic molecule non-covalently bound to the PVC polymer, that leaches from the plastics when in contact with the stored blood component.
- Why is DEHP used as a plasticizer?
- Due to its low cost and generally good performance, DEHP is widely employed as a plasticizer in manufacturing articles made of PVC. Melting point: −50°C Boiling point: 250 - 257°C at 0.5 kPa DEHP offers good gelling, satisfactory electrical properties and helps to produce highly elastic compounds with reasonable cold strength.
- Which phthalate plasticizer is used in medical devices?
- DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
- What is DEHP used for?
- Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks.
- How much DEHP is in plastic?
- Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide.
- Which terephthalate is a good replacement for DEHP?
- Terephthalate esters, particularly di-2-ethylhexyl terephthalate, are the most popular replacements for DEHP. They are less compatible with PVC. But their low cost and long history as commercial plasticizers are their most attractive features. Dialkyl terephthalates with sidechains containing:
- Which plasticizer is most commonly used?
- Di- (2-ethylhexyl)-phthalate (DEHP) has been the most widely used plasticizer since its introduction in 1930. However, the non-covalent bond between DEHP (or plasticizers in general) and polymers mean they can be leached when they enter into contact with fluids containing lipophilic compounds .
