Effective role of eco-friendly acetyl tributyl citrate
Acetyl tributyl citrate (ATBC) is widely recognized as an eco-friendly, non-petroleum-based, and biodegradable plasticizer that has been widely used in biomedical and biodegradable materials and food packaging films (Bae et al., 2015; Fang et al., 2018; Rp et al., 2016).
Phthalate alternative may harm brain development and health
Researchers found that the chemical acetyl tributyl citrate (ATBC) might not be the best replacement. FULL STORY Growing concerns over the potential health effects of exposure to...
Preparation and evaluation of acetylated mixture of citrate
TBC, ATBC, triisooctyl citrate (TOC) and acetyl triisooctyl citrate (ATOC) have been used in soft PVCs for more than half a century, and their toxicity is well studied [ 22, 23 ]. The results have indicated that citrates are safe plasticizers without reproductive toxicity.
Analysis of the most appropriate risk management option (RMOA)
tributyl ester Acetyl tributyl citrate Type of substance Mono-constituent Multi-constituent UVCB Structural formula: 1.2 Similar substances/grouping possibilities The tributyl citrate (TBC, EC No 201-071-2) registrant proposed in its dossier a category approach with TEC, ATEC, ATBC and ATEHC (see FR RMOA on TBC). The read-
Acetyl Tributyl Citrate, the Most Widely Used Phthalate
In particular, acetyl tributyl citrate (ATBC), an industrial plasticizer widely used in products such as food wrap, vinyl toys, and pharmaceutical excipients, strongly activated human and rat SXR. ATBC increased CYP3A4 messenger RNA (mRNA) levels and enzyme activity in the human intestinal cells but not in human liver cells.
- What is acetyl trityl citrate (ATBC)?
- IDENTIFICATION AND USE: Acetyl tributyl citrate (ATBC) is a colorless liquid. It is the most widely used phthalate substitute plasticizer. It is used in products such as food wrap, vinyl toys, and pharmaceutical excipients. It is also used as a flavor ingredient in non-alcoholic beverages.
- What are the metabolites of 14c-acetyl tributyl citrate?
- Both the absorption and metabolism of 14C-Acetyl tributyl Citrate proceeded rapidly, and the following metabolites were identified: acetyl citrate, monobutyl citrate, acetyl monobutyl citrate, dibutyl citrate, and acetyl dibutyl citrate. Membrane CIR ingredient: Acetyl Tributyl Citrate
- What is acetyl tributyl citrate?
- Acetyl tributyl citrate is a flavouring ingredient and plasticiser used in packaging films for food. Conformer generation is disallowed since too flexible tributyl 2-acetyloxypropane-1,2,3-tricarboxylate InChI=1S/C20H34O8/c1-5-8-11-25-17 (22)14-20 (28-16 (4)21,19 (24)27-13-10-7-3)15-18 (23)26-12-9-6-2/h5-15H2,1-4H3 QZCLKYGREBVARF-UHFFFAOYSA-N
- How many workers are exposed to acetyl tributyl citrate?
- NIOSH (NOES Survey 1981-1983) has statistically estimated that 106,672 workers (98,182 of these are female) are potentially exposed to acetyl tributyl citrate in the US (1).
- Does acetyl tributyl citrate have slight mobility in soil?
- TERRESTRIAL FATE: Based on a classification scheme (1), an estimated Koc value of 3280 (SRC), determined from a log Kow of 4.90 (2) and a regression-derived equation (3), indicates that acetyl tributyl citrate is expected to have slight mobility in soil (SRC).
- Is acetyl tributyl citrate a carcinogen?
- ECOTOXICITY STUDIES: For acetyl tributyl citrate, the 96-hr LC50 values for fish range from 38 to 60 mg/L, the 48-hr EC50 value for aquatic invertebrates is 7.8 mg/L and the 72-hr EC50 values for aquatic plants are 11.5 mg/L for biomass and 74.4mg/L for growth rate, respectively. No indication of carcinogenicity to humans (not listed by IARC).
