TEC Plasticization of Topical Polymeric Films | SpringerLink
The incorporation of plasticizers into polymer films increases their flexibility [4] and permits the mechanical properties to be matched to those of skin. In this way, film breakage is avoided and the area across which drug transport occurs remains constant.
Topical Polymeric Films and Transdermal Patches | BASF Pharma
Develop a broad range of topical polymeric films and transdermal patches with our diverse selection of film formers, matrix formers, plasticizers, and solvents. Explore Our Diverse Product Portfolio Kollicream Mild emollients aiding in the dermal penetration of active ingredients View products Kollisolv
Polymeric Plasticizers - Chemicals
Polymeric Plasticizers Polymer plasticizers or polyadipates are polyesters of aliphatic dicarboxylic acids. BASF manufactures and markets the following polymer plasticizers for special applications:
Exploiting Polymeric Films as a Multipurpose Drug Delivery
Polymeric films are drug delivery systems that maintain contact with the delivery tissue and sustain a controlled release of therapeutic molecules. These systems allow a longer time of drug contact with the target site in the case of topical treatments and allow the controlled administration of drugs. They can be manufactured by various methods such as solvent casting, hot melt extrusion
Formulation considerations in the design of topical, polymeric film
Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Their application convenience and cosmetic attributes, superior to conventional semi-solids, may offer improved patient compliance.
- How can plasticizers be used to make polymers soft and flexible?
- By adding plasticizers to compatible polymers, the materials can be modified in such a way that they become soft and flexible by decreasing their glass transition temperature. Plasticizers are classified according to their molecular structure into monomeric or polymeric types.
- How are plasticizers classified?
- Plasticizers are classified according to their molecular structure into monomeric or polymeric types. The choice of the plasticizer is dependent on the requirements that have to be met for the final product and the conditions around that product’s use.
- What are the benefits of topical polymeric films & transdermal patches?
- Due to their benefits such as physical barrier formation, ease of application, and reduced dosing frequency, topical polymeric films and transdermal patches are often associated with improved patient compliance.
- How do plasticizers affect polymers?
- Plasticizers are substances which, by virtue of their polar or polarizable structure, weaken the secondary valence forces of polymers. By adding plasticizers to compatible polymers, the materials can be modified in such a way that they become soft and flexible by decreasing their glass transition temperature.
- What are plasticizers & modifiers?
- Plasticizers and Modifiers are part of the Polymer Additive Business Unit and comprise of a wide range of high-quality products under the brand names Mesamoll ®, Adimoll ®, Unimoll ®, Ultramoll ®, K-FLEX ®, Vitroflex ®, Modulast ®, Uniplex ®, Triacetin, Acetine, and Baymod®. Mesamoll ® is a phthalate-free universal monomeric plasticizer.
- How to choose a plasticizer?
- The choice of the plasticizer is dependent on the requirements that have to be met for the final product and the conditions around that product’s use. This may include low volatility, high permanence, low temperature flexibility, flame retardancy, high thermal stability and saponification resistance.
