NHANES 2013-2014 Overview - Centers for Disease Control and Prevention
NHANES 2013-2014 Overview Introduction The National Center for Health Statistics (NCHS), Division of Health and Nutrition Examination Surveys (DHANES), part of the Centers for Disease Control and Prevention (CDC), has conducted a series of health and nutrition surveys since the early 1960's.
NHANES 2013-2014: Phthalates and Plasticizers Metabolites - Urine Data
NHANES 2013-2014: Phthalates and Plasticizers Metabolites - Urine Data Documentation, Codebook, and Frequencies National Health and Nutrition Examination Survey 2013-2014 Data Documentation, Codebook, and Frequencies Phthalates and Plasticizers Metabolites - Urine (PHTHTE_H) Data File: PHTHTE_H.xpt First Published: December 2016
PHTHTE_J - Centers for Disease Control and Prevention
Phthalates are used widely in polyvinyl chloride plastics, which are used to make products such as plastic packaging film and sheets, garden hoses, inflatable toys, blood-storage containers, and medical tubing. 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) is used as a replacement of some high molecular weight phthalates.
SSPHTE_H - Centers for Disease Control and Prevention
We recently modified the original analytical method used at CDC for measuring phthalate metabolites, so we could include two oxidative metabolites of DBP and DiBP, mono-3-hydroxy-n-butyl phthalate (MHBP) and mono-2-hydroxy-iso-butyl phthalate (MHiBP), from NHANES 2013-2014. Eligible Sample
Non-persistent exposures from plasticizers or plastic
Personal care product use among adults in NHANES: associations between urinary phthalate metabolites and phenols and use of mouthwash and sunscreen. J Expo Sci Environ Epidemiol. 2016;27:326–32.
- Which phthalate metabolites are available in the NHANES database?
- Flow chart algorithm There are four urinary DEHP metabolites available in the NHANES 2013–2014 database, including mono (2-ethylhexyl) phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP), mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono (2-ethyl-5-carboxypentyl) phthalate (MECPP).
- Are phthalates endocrine disruptors?
- Phthalates are plasticizers in various products and regarded as endocrine disruptors due to their anti-androgen effects. Environmental occurrence and toxicities of parent phthalates have been widely reported, while the current state of knowledge on their metabolites is rarely summarized.
- Which metabolites are measured in NHANES 2013-2014?
- In NHANES 2013–2014, urinary DEHP metabolites were measured in one-third of participants aged 6 years and older, and serum NfL was assessed in one-half of subjects aged 20 to 75 years. Out of the 9770 participants, data for both covariates were available for 701 study subjects.
- How phthalates are metabolized?
- Phthalates can be rapidly metabolized to their respective primary monoesters and further to oxidized metabolites in human body (Guo et al., 2011b). In detail, normally metabolic pathway of phthalates involves two steps: in the first phase, phthalates are metabolized to monoesters by esterase and lipase in intestines or other tissues.
- How do phthalate metabolites differ from parent phthalates?
- Metabolites display different toxic mechanism compared to parent phthalates. Differences exist in distribution of phthalate metabolites in multiple human specimens. Urinary profiles of phthalates vary markedly for people on different continents. Reasonable FUE data are suggested for phthalate exposure assessment by human experiments.
- What models are used to estimate human daily intake of phthalates?
- The following models used to estimate human daily intake (EDI) of phthalates are mainly based on their excretion rates and urinary mPAE concentrations (Table S4). The model M1 was initially proposed by David (2000) and Kohn and Needham (2000), which was enlightened by a report from Blount et al. (2000b).
