The molecular interactions that influence the plasticizer dependent
The molecular interactions that influence the plasticizer dependent dissolution of acrylic polymer films Poly(methacrylic acid-methyl methacrylate, 1:2) (Eudragit S) is a commonly used pH-responsive polymer that can facilitate delivery to the ileo-colonic region of the gastrointestinal tract.
The Molecular Interactions That Influence the Plasticizer Dependent
A miscible plasticizer increases film flexibility by reducing intermolecular interactions between individual polymer molecules; 8 this can influence drug release. 9 It has been proposed that plasticizer enhancement of polymer mobility alters the distribution of diffusion channels and therefore drug diffusion through the water-insoluble polymer systems. 10 However studies have not substantiated
The molecular interactions that influence the plasticizer dependent
Different plasticizers have been used to reduce the brittleness of Eudragit S films for the coating of solid dosage forms. To better correlate the dissolution rates of Eudragit S films, we have examined their dielectric response to understand the specific polymer–plasticizer interactions.
The molecular interactions that influence the plasticizer dependent
Low temperature TSDC spectra showed a relationship of the total secondary relaxation area and relaxation of the carboxylic acid functional group with dissolution time, suggesting dielectric secondary relaxations may be a good probe to predict plasticizer influence on dissolution of Eudragit S polymer films. Poly(methacrylic acid-methyl methacrylate, 1:2) (Eudragit S) is a commonly used pH
Determination of plasticizers efficiency for nylon by molecular
Plasticizers are incorporated in the amorphous parts of polymers while the structure and size of any crystalline part remains unaffected [ 2 ]. Plasticizer efficiency is defined as a measure of the concentration of plasticizer required to impart a specified softness to a polymer [ 2 ]. Plasticizer efficiency is greatly influenced by structural
- How do plasticizers interact with the polymer matrix?
- Since the plasticizers are relatively small molecules which are not chemically bound to 2 the polymer matrix, they can interact in MDs both with the polymer matrix and the drug solution. Two other phenomena known as leaching and sorption may compete each other and lead to adverse effects for the patient.
- How do drug molecules interact with plasticizers?
- This means that as the drug molecules adsorb onto the surface they interact with PVC, water and also plasticizers as clearly shown by Figure 5d and Figure S7d.
- Can plasticizer molecules leave the PVC material through migration?
- However, this could mean that plasticizer molecules, which are not chemically attached to polymer chains, could in certain conditions leave the PVC material through migration but the duration of our simulations is not long enough to observe to this phenomenon.
- Does polymer chain separation affect the aqueous solubility of a plasticizer?
- This dependency of polymer chain separation and reduction of the intermolecular forces between them on the aqueous solubility of the plasticizer contrasts with the DSC results obtained for the poly (methacrylic acid ethylacrylate) copolymer (Eudragit L100-55) films39 that were plasticized with the same additives as those used in the present work.
- Who are the authors of drug interactions with plasticized PVCs?
- Drug Interactions with Plasticized PVCs Author Meriem Sahnoune, Nicolas Tokhadzé, Sarah Ech Cherif El Kettani, Julien Devémy, Florent Goujon, Philip Chennell, Alain Dequidt, Christelle Goutaudier, Valérie Sautou, Patrice Malfreyt Subject
- How does hydrogen bonding affect polymer-polymer interactions?
- Hydrogen bonding with a plasticizer may weaken intermolecular polymer–polymer interactions. This can potentially increase the propensity for water imbibation into the films to facilitate faster dissolution times.
