Plasticizers and Cardiovascular Health: Role of Adipose
Concern over the toxicity of plasticizers arose in the late 1990s, largely focused around adverse developmental and reproductive effects. More recently, many studies have demonstrated that exposure to plasticizers increases the risk for obesity, type 2 diabetes, and cardiovascular disease (CVD).
Frontiers | Plasticizers and Cardiovascular Health: Role
There are two main groups of plasticizers: 1) bisphenols, which confer rigidity to hard polycarbonate plastics and 2) phthalates, which provide flexibility to soft plastics and polyvinyl chloride (PVC) products. A large body of evidence indicates that these plastics interfere with adipocyte differentiation and adipose tissue function.
Plasticizers and Cardiovascular Health: Role of Adipose
More recently, many studies have demonstrated that exposure to plasticizers increases the risk for obesity, type 2 diabetes, and cardiovascular disease (CVD). In the 2000s, many governments including Canada, the United States and European countries restricted the use of certain plasticizers in products targeted towards infants and children.
Plasticizers and Cardiovascular Health: Role of Adipose
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Plasticizer Interaction With the Heart | Circulation
Plastics have revolutionized clinical care. Yet, despite the many advantages, concerns have been raised about the ubiquitous use of plastics in the clinical setting. 1–3 To manufacture flexible plastic products, phthalate esters are added to impart flexibility to otherwise stiff polyvinyl chloride polymers.
- Are plasticizers harmful to adipose tissue?
- Adipose tissue has been well-documented to be a target of the disrupting effects of both bisphenols and phthalates. Since adipose tissue function is a key determinant of cardiovascular health, adverse effects of plasticizers on adipocyte signaling and function may underlie their link to cardiovascular disease.
- Can plastic polymers cause cardiovascular disease?
- New evidence has emerged that plastic polymers and their chemical additives, particularly di-2-ethylhexylphthalate (DEHP), contribute to cardiovascular disease (CVD). Phthalates are commonly used in the production of plastic materials and have been linked to increased oxidative stress, metabolic dysfunction, and cardiovascular disease.
- Are plasticizers toxic?
- Concern over the toxicity of plasticizers arose in the late 1990s, largely focused around adverse developmental and reproductive effects. More recently, many studies have demonstrated that exposure to plasticizers increases the risk for obesity, type 2 diabetes, and cardiovascular disease (CVD).
- What are plasticizers & how do they affect human health?
- Plasticizers, additives that modify the flexibility and rigidity of the product, are ingested as they migrate into food and beverages. Human exposure is continuous and widespread; between 75 and 97% of urine samples contain detectable levels of bisphenols and phthalates, the most common plasticizers.
- How do plasticizers affect adipose function?
- Many plasticizers can alter adipose function by disrupting endocrine signaling in adipose tissue. Obesogenic effects leading to adipocyte hypertrophy and dysfunction may account for dysregulated adipokine release, or EDC may directly influence the endocrine function of adipose tissue.
- Do plastic-related chemicals contribute to cardiovascular mortality in the 55–64 age group?
- Our findings reveal that plastic-related chemicals significantly contribute to cardiovascular mortality in the 55–64 age group, highlighting an under-recognised but critical environmental health issue. The global burden of DEHP exposure, especially in vulnerable populations, calls for immediate regulatory action to mitigate these risks.
