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  • Are plasticizers effective as processing aids for HME process?
  • The physical and mechanical properties of plasticizers, in selected binary (polymer:plasticizer) and ternary (active pharmaceutical ingredient:polymer:plasticizer) systems, were evaluated to assess their effectiveness as processing aids for HME process.
  • What are plasticizers used for?
  • Plasticizers have been added to the formulation to reduce T g of the polymers . They are also useful in the HME process to overcome stickiness and charging of polymer to walls of HME equipment. ... ...
  • Can plasticizers be used in extrusion processing?
  • The addition of plasticizers as a strategy to facilitate the extrusion processing is well established in the plastics and pharmaceutical industries (62). Plasticizers are typically small molecules that act to increase the free volume between polymer chains, resulting in a depression of the T g and the melt viscosity (63).
  • Do plasticizers affect HME process and product performance?
  • Although various studies have demonstrated the effect of plasticizers on HME process and product performance, 21, 22, 23, 24, 25 no single study has investigated the systematic approach for selecting a suitable plasticizer.
  • What plasticizers are used in hot-melt extruded systems?
  • Although commonly used pharmaceutical plasticizers such as triacetin, 4 citrate esters, 2, 5 and lower molecular weight polyethylene glycols 2, 3, 4 have been investigated in hot-melt extruded systems, almost all of them are liquid.
  • What is a solid state plasticizer?
  • Based on comparable solubility parameters, stearic acid, glyceryl behenate, and polyethylene glycol 8000 were selected as solid-state plasticizers. Binary and ternary physical mixtures were evaluated as a function of plasticizer concentration for thermal and rheological behavior.