Pharmaceutical Tablet Film Coatings | PharmaCentral
A film coating is constituted from a variety of materials that include a polymer, a plasticizer, and other additives (surfactant, colorants/pigments and lubricants). Once combined and dissolved or dispersed in a solvent or aqueous medium, the different ingredients are sprayed onto the substrate and allowed to form a thin, continuous envelope.
Film coating | SEPPIC
The film-coating formulation combines four key ingredients: A film-forming polymer, which provides the mechanical strength of the film. The most widely used polymers in non-functional film coating are cellulose derivatives such as hypromellose. Plasticizers, used to improve the flexibility of the film formed and prevent it from cracking or
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Pharmaceutically Used Plasticizers - IntechOpen
phase. Subsequently, the plasticizer diffuses in to the polymer particles. A sufficient amount of time for plasticizer uptake by the polymer particles is necessary to avoid forming an inhomogeneous plasticized system (Bodmeier Paeratakul, 1997). 2.1.4 Plasticizer leaching out of polymer and methods of reduction
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- What are plasticizers used for?
- Plasticizers are additives that increase the plasticity or fluidity of a material. Coating formulations based on physically drying binders such as nitrocellulose, require external plasticizers for optimal film formation. They are used to control the film formation process of coatings based on physically drying film-forming materials.
- Can plasticizers be used in coating formulations?
- For natural products or hard polymers of poor processing, the option is the external use of plasticizers in the coating formulations. Plasticizers interact physically with the polymer binder molecule, without a chemical reaction and form a homogeneous system.
- Which plasticizers are used in coatings?
- Commonly used plasticizers in coatings are: DINCH (dicarboxylate) and more. Plasticizers may be solvents or non-solvents to the binder. For example, NC is soluble in plasticizers such as di-butyl phthalate (DBP), di-iso-octyl phthalate (DIOP), di-octyl phthalate (DOP) & tricresyl phosphate.
- Is ATBC a safe plasticizer?
- ATBC is considered as a safe, low toxicity, alternative plasticizer demonstrating improved biodegradability and biochemical properties, as compared to phthalates. ATBC is widely used now for NC coatings as well as NC food packaging inks & packaging of medical products.
- What are external plasticizers?
- Main external plasticizers are low molecular weight materials, demonstrating fast interaction with the polymer chain. However, in specific cases also, polymers are used as plasticizing material. For instance, NC lacquers may be modified using synthetic resins such as alkyd resins to control flexibility and reduce brittleness.
- What is DOP plasticizer?
- DOP or DnOP is light-colored, low volatility & odorless liquid. It was the most commonly used all-purpose plasticizer, although mainly used for polyvinyl chloride (PVC) resins. It is insoluble in water & has a low viscosity of 56 mPa.s at 25°C. DOP features:
