Selection of Solid-State Plasticizers as Processing Aids
Based on comparable solubility parameters, stearic acid, glyceryl behenate, and polyethylene glycol 8000 were selected as solid-state plasticizers. Binary and ternary physical mixtures were evaluated as a function of plasticizer concentration for thermal and rheological behavior.
Selection of Solid-State Plasticizers as Processing Aids
Selection of Solid-State Plasticizers as Processing Aids for Hot-Melt Extrusion - ScienceDirect Journal of Pharmaceutical Sciences Volume 107, Issue 1, January 2018, Pages 372-379 Research Article Pharmaceutics, Drug Delivery and Pharmaceutical Technology Selection of Solid-State Plasticizers as Processing Aids for Hot-Melt Extrusion
Selection of Solid-State Plasticizers as Processing Aids
Based on comparable solubility parameters, stearic acid, glyceryl behenate and PEG 8000 were selected as solid state plasticizers. Binary and ternary physical mixtures were evaluated as a...
Selection of Solid-State Plasticizers as Processing Aids
The physical and mechanical properties of plasticizers, in selected binary (polymer:plasticizer) and ternary (active pharmaceutical ingredient:polymer:plasticizer) systems, were evaluated to assess their effectiveness as processing aids for HME process. were selected as solid-state plasticizers.
Food Processing Aids - Canada.ca
The Food Directorate informally defines a food processing aid as a substance that is used for a technical effect during food processing or manufacture but, unlike food additives, its use does not affect the intrinsic characteristics of the food and it results in no or negligible residues of the substance or its by-products in or on the finished
- Are plasticizers effective as processing aids for HME process?
- The physical and mechanical properties of plasticizers, in selected binary (polymer:plasticizer) and ternary (active pharmaceutical ingredient:polymer:plasticizer) systems, were evaluated to assess their effectiveness as processing aids for HME process.
- What is a solid state plasticizer?
- Based on comparable solubility parameters, stearic acid, glyceryl behenate, and polyethylene glycol 8000 were selected as solid-state plasticizers. Binary and ternary physical mixtures were evaluated as a function of plasticizer concentration for thermal and rheological behavior.
- Which solid-state plasticizers are used in a chemistry study?
- Solubility parameters, thermal analysis, and rheological evaluation were used as assessment tools. Based on comparable solubility parameters, stearic acid, glyceryl behenate, and polyethylene glycol 8000 were selected as solid-state plasticizers.
- How to select solid-state plasticizer?
- The selection of solid-state plasticizer should include miscibility of plasticizer in polymer as well as API and its effect on T g and η 0 of the final system. It can be summarized that when components are miscible, different techniques will lead to the consistent plasticization effect prediction.
- Which reagents are used in solid-state plasticizers?
- Stearic acid (SA) (Mallinckrodt) glyceryl behenate (GB) (Gattefossé, Saint-Priest, France), and polyethylene glycol (PEG) 8000 (Dow-Union Carbide) were selected as solid-state plasticizers to be investigated. All other reagents were of analytical grade.
- Do Plasticizers improve formulation performance and stability?
- Although these plasticizers are effective as processing aid for HME, the effect of these plasticizers on formulation performance and stability is of utmost interest for the development of stabilized amorphous formulations. J. Swarbrick, J.C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology (19th ed.), Marcel Dekker Inc.,
