Searching for Alternative Plasticizers for Red Blood Cell
Currently, DEHP (di- (2-ethylhexyl) phthalate) is the “softener” used in blood bag production to provide the necessary durability and flexibility, as an example for red blood cell (RBC) storage. However, DEHP is known to leach out of the plastic blood bag into the RBC suspension and exposures to high levels of DEHP have been shown to cause
Di(2-ethylhexyl) phthalate (DEHP) in Canadians - Canada.ca
DEHP is identified as toxic under the Canadian Environmental Protection Act, 1999. It is on the List of Ingredients that are Prohibited for Use in Cosmetic Products. Regulations limit the use of DEHP in soft vinyl toys and child-care articles.
A potentially general approach to aliphatic ester-derived PVC
The safety of flexible polyvinyl chloride (PVC) materials is now being questioned, partially due to allegations that di-(2-ethylhexyl) phthalate (DEHP), the dominant PVC plasticizer, is an endocrine disruptor and a probable carcinogen. As sustainable alternatives, aliphatic ester-derived plasticizers feature
Blood Bag Plasticizers Influence Red Blood Cell Vesiculation
RBC mean cell volumes were greater in BTHC- than in DINCH- or DEHP-plasticized bags (p < 0.001). Osmotic fragility differed significantly among plasticizers (p < 0.01). After day 21, RBC deformability decreased in all, but to a greater extent in the bags with BTHC. Phospholipid composition of RBCs and EVs was not different among plasticizers.
Non-phthalate plasticizer DEHT preserves adequate blood
DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming regulatory restrictions for DEHP due to toxicity concerns increase the urgency to replace DEHP without compromising RBC quality.
- Which phthalate plasticizer is used in Canada?
- Additionally, DEHP is a skin, eye, and respiratory tract irritant. DEHP was not included in other Canadian government guidelines, standards, or chemical listings reviewed. Di (2-ethylhexyl) phthalate is the most important phthalate plasticizer used in Canada.
- Is DEHP a phthalate?
- DEHP (CASRN 117-81-7) is part of a class of synthetic chemicals known as phthalates. Phthalates are used as solvents in household products and as plasticizers to make plastics more flexible and resilient. Where is DEHP found?
- Is DEHP biomonitoring in Canada?
- Information on human biomonitoring of DEHP in Canada with results from the Canadian Health Measures Survey. What is di (2-ethylhexyl) phthalate (DEHP)?
- DEHP (CASRN 117-81-7) is part of a class of synthetic chemicals known as phthalates.
- Which phthalate plasticizer is used in medical devices?
- DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
- How much DEHP is in plastic?
- Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide.
- How is DEHP Released in Canada?
- Searches of Environment Canada’s National Pollutant Release Inventory (NPRI) database yielded the following results for DEHP release in Canada: Occupational exposure to DEHP occurs by inhalation of its aerosol or mist form, which is a result of its very low vapour pressure. [1, 2]
