Simultaneous and sensitive determination of the main
With the prominent but toxicologically critical plasticizer di-(2-ethylhexyl) phthalate (DEHP) declining, alternative plasticizers are increasingly used leading to a continuously more diverse exposure situation of humans with multiple plasticizers. Therefore, an on-line SPE-LC-MS/MS method for the simultaneo
Simultaneous determination of plasticizer di(2-ethylhexyl
Simultaneous determination of plasticizer di (2-ethylhexyl)phthalate and its metabolite in human urine by temperature controlled ionic liquid dispersive liquid–liquid microextraction combined with high performance liquid chromatography - Analytical Methods (RSC Publishing) Issue 6, 2013 Previous Article Next Article From the journal:
Simultaneous determination of di(2-ethylhexyl) phthalate and
Simultaneous determination of di (2-ethylhexyl) phthalate and diisononylcyclohexane-1,2-dicarboxylate and their monoester metabolites in four labile blood products by liquid chromatography tandem mass spectrometry . 2025 Mar 20;181:113063. doi: 10.1016/j.jpba.2025.113063. Epub 2025 Dec 23. Authors
Simultaneous determination of polyvinylchloride plasticizers
Di (2-ethylhexyl) phthalate (DEHP) and tri (2-ethylhexyl) trimellitate (TEHTM or TOTM) are common plasticizers that are also largely used for PVC medical devices, e.g. bags and tubing for blood transfusions and infusions. The leachability of medical devices is a well-known situation of increasing toxicological concern.
Simultaneous determination of polyvinylchloride plasticizers
To assess the migration of plasticizers from PVC medical devices into human blood we developed and validated an analytical method for the determination of DEHP and TOTM in combination with the determination of their primary degradation products mono(2-ethylhexyl) phthalate (MEHP), 1,2-di(2-ethylhexyl) trimellitate (1,2-DEHTM) and 2-mono(2
- Is di (2-ethylhexyl terephthalate) a DEHP alternative?
- Regarding di (2-ethylhexyl)terephthalate (DEHT), it could be considered as a potential DEHP alternative although hemolysis values were higher than DEHP . According to the Scenihr report , DINCH is considered as non-genotoxic and non-carcinogen. It is neither a reproductive toxicant nor an endocrine disruptor in rodents .
- What is tehtm plasticizer?
- Simultaneous analysis of acidic and neutral analytes by MS/MS potential switching. Di (2-ethylhexyl) phthalate (DEHP) and tri (2-ethylhexyl) trimellitate (TEHTM or TOTM) are common plasticizers that are also largely used for PVC medical devices, e.g. bags and tubing for blood transfusions and infusions.
- Which biomarkers are associated with exposure to DEHP and alternative plasticizers?
- Therefore, an on-line SPE-LC-MS/MS method for the simultaneous determination of the most relevant urinary biomarkers of exposure to DEHP and the alternative plasticizers 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH), di-(2-ethylhexyl) terephthalate (DEHTP) and tri-(2-ethylhexyl) trimellitate (TEHTM) was developed.
- Are plasticizer DEHP and MEHP metabolites detectable in low concentrations?
- In contrast, the plasticizer DEHP as well as its metabolite MEHP were detectable in every sample in low concentrations with mean levels of 0.193 ± 0.078 mg/L and 0.004 ± 0.007 mg/L, respectively. The blank values were always taken into account by subtraction (cf. Section 2.5 ).
- Does solvent composition affect the extraction recovery of plasticizers?
- Influence of the solvent composition on the extraction recovery of plasticizers (DEHP, DINCH) and their corresponding monoester metabolites (MEHP, MINCH), calculated in (A) plasma and (B) red cells concentrate. Mean recoveries were calculated from three independent determinations (RSD < 10 %).
- Are plasticizers leachable?
- As shown, the leachability of plasticizers depends on the nature of the biological matrix. Indeed, plasticizer concentrations were higher in plasma and WB (mean values of 48 and 7 μM for DEHP and DINCH, respectively) than RCC and PC (mean value of 17 and 2 μM for DEHP and DINCH, respectively).
