A potentially general approach to aliphatic ester-derived PVC
As sustainable alternatives, aliphatic ester-derived plasticizers feature low cytotoxicity, biodegradability, and renewability, but they can only partially replace DEHP in PVC formulations because they have a strong tendency to migrate.
Simultaneous and sensitive determination of the main metabolites of the
With the prominent but toxicologically critical plasticizer di-(2-ethylhexyl) phthalate (DEHP) declining, alternative plasticizers are increasingly used leading to a continuously more diverse exposure situation of humans with multiple plasticizers. Therefore, an on-line SPE-LC-MS/MS method for the simultaneo
Non-phthalate plasticizer DEHT preserves adequate blood
DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming regulatory restrictions for DEHP due to toxicity concerns increase the urgency to replace DEHP without compromising RBC quality.
Non‐phthalate plasticizer DEHT preserves adequate blood component
Plasticizers are essential for material flexibility; facilitating centrifugation, sealing, transport and general handling of blood bags without risk of breakage and product loss . DEHP is a dipolar, lipophilic molecule non-covalently bound to the PVC polymer, that leaches from the plastics when in contact with the stored blood component.
DEHT is a suitable plasticizer option for phthalate-free storage
Abstract Background and objectives: Due to increasing concerns about possible endocrine-disrupting properties, the use of the plasticizer di (2-ethylhexyl) phthalate (DEHP) will be banned in future blood storage. Di (2-ethylhexyl) terephthalate (DEHT) provides sufficient red blood cell (RBC) quality during conventional blood bank storage.
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- Can DEHP be used in PVC medical devices?
- The use of DEHP in PVC medical devices was therefore challenged by the European authorities (European Union, R 2007), and in 2012 a French law banned the use of DEHP in plasticized PVC medical tubing in neonatology and maternity services as from July 1, 2015 (French law, 2012).
- Is DEHP safe in medical devices?
- Also for DEHP a so called tolerable daily intake (TDI) was calculated in recent risk evaluations. Therefore an overview is presented on the safety of DEHP in medical devices. In addition, the availability, suitability and safety of alternative plasticizers for DEHP have been evaluated. Alternative materials for PVC were not evaluated.
- What is DEHP used for?
- Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks.
- Are medical devices containing DEHP Plasticized PVC dangerous?
- In September 2002, the Scientific Committee on Medicinal Products and Medical Devices adopted an opinion on “Medical Devices containing DEHP plasticized PVC; Neonates and Other Groups Possibly at Risk from DEHP toxicity” according to which “there is no evidence that any of these groups do experience DEHP related adverse effects”.
- Which phthalate plasticizer is used in medical devices?
- DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
