Plasticizer Excipients | American Pharmaceutical Review
Plasticizer Excipients Plasticizers are used mainly for oral solid dosage forms. Plasticizers are added to the polymers used as film forming agents in order to make the polymer pliable and soft, enhancing the flexibility and plasticity of the films.
Plasticizer Excipients, Inert Pharmaceutical Ingredients
Plasticizer excipients provide flexibility and permeability of the capsule film coating and are considered effective in retarding drug release in acid media. Choose from our wide selection below, including propylene glycol, glycerin, polyethylene glycol, and much more.
Plasticizer Excipients - CD Formulation
According to solubility: The glycerin in water-soluble plasticizer capsules is commonly used polyethylene glycol 200, polyethylene glycol 400, propylene glycol and so on. Water-insoluble plasticizer castor oil, acetylated monoglycerides, phthalic acid esters, etc. According to chemical structure:
Plasticizers: A Vital Excipient in Novel Pharmaceutical
plasticizer excipients. 6. Typically the plasticizers are used in the concentration of 0–20 percent w/v of dry polymer weight. However, inappropriate use of plasticizer may prompt to film breaking, splitting and peeling of the strip. 7. It is also reported that the use of certain plasticizers may
Excipients for Amorphous Solid Dispersions | SpringerLink
The classification of various excipients is categorized in detail, covering polymers, solubilizers, plasticizers, antioxidants, and other suitable fillers. The impact of excipients on various amorphous solid dispersion technologies is also discussed in detail.
- What plasticizers are used in hot-melt extruded systems?
- Although commonly used pharmaceutical plasticizers such as triacetin, 4 citrate esters, 2, 5 and lower molecular weight polyethylene glycols 2, 3, 4 have been investigated in hot-melt extruded systems, almost all of them are liquid.
- Which type of plasticizer is best for extrusion?
- PEG–VCap–VAc is characterized by the widest temperature range for extrusion, followed by povidone 12, and copovidone. The type of plasticizer has a major influence on Tg, melt viscosity, and the temperature range of the polymer in the HME process. A plasticizer principally enables extrusion processes to occur at low temperatures.
- Are plasticizers effective as processing aids for HME process?
- The physical and mechanical properties of plasticizers, in selected binary (polymer:plasticizer) and ternary (active pharmaceutical ingredient:polymer:plasticizer) systems, were evaluated to assess their effectiveness as processing aids for HME process.
- How does a plasticizer affect the extrusion process?
- A plasticizer principally enables extrusion processes to occur at low temperatures. The knowledge of polymer and plasticizer characteristics and their effects on the extrusion process and resulting extrudates is an important prerequisite for the quick and successful development of an extruded drug-delivery system.
- Are plasticizers miscible with API and polymer?
- Based on the solubility parameter, plasticizers such as SA, GB, and PEG showed Δδ (API) and Δδ (polymer) < 7 MPa ½, and they are likely to be miscible with the API and polymer. These plasticizers are expected to form a one-phase system with the INM-EPO mixture.
- What are some examples of plasticizers used in hot-melt extrusion?
- Plasticizers such as mannitol, sorbitol, and meglumine are sometimes required to soften the polymeric material and facilitate the extrusion process, notes Philip Schäfer, head of Business Franchises, Process Solutions, MilliporeSigma, the US and Canada Life Science Business of Merck KGaA, Darmstadt, Germany.
