Analytical methods for the determination of DEHP plasticizer
It was also successfully used by Rothenbacher et al. [50] to determine if a rapid screening test for plasticizers (like DEHP, DINP, or DINCH) in PVC materials can be developed using direct analysis in real time mass spectrometry (DART-MS). An open interface would allow the direct insertion of solid specimens, such as samples of medical devices.
A potentially general approach to aliphatic ester-derived PVC
The safety of flexible polyvinyl chloride (PVC) materials is now being questioned, partially due to allegations that di-(2-ethylhexyl) phthalate (DEHP), the dominant PVC plasticizer, is an endocrine disruptor and a probable carcinogen. As sustainable alternatives, aliphatic ester-derived plasticizers feature
Diverging trends of plasticizers (phthalates and non
In recent house dust samples, Di (2-ethylhexyl) terephthalate (DEHT) had the third highest concentration of all plasticizers and contributed 18% to the total load, whereas Tris (2-ethylhexyl) trimellitate (TOTM) was one of the major non-phthalates in SPM samples. Conclusions
Patients’ exposure to PVC plasticizers from ECMO circuits
With the prominent but toxicologically critical plasticizer di-(2-ethylhexyl) phthalate (DEHP) declining, alternative plasticizers are increasingly used leading to a continuously more diverse
Non-phthalate plasticizer DEHT preserves adequate blood
DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming regulatory restrictions for DEHP due to toxicity concerns increase the urgency to replace DEHP without compromising RBC quality.
- How much DEHP is in plastic?
- Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide.
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- How to identify alternative plasticizers?
- It is easy to obtain general information using very simple non-separative methods suitable for identifying the alternative plasticizers. These methods rely on the general features of polymers, like PVC and their plasticizers, such as thermolability and spectral and electromagnetic characteristics.
- Which plasticizers are used in MDS?
- The review focuses on the aternative to DEHP plasticizers currently used in the MDs. Their migration from PVC depends partially on their physicochemical properties. The patient׳s exposure is the main risk and has to be investigated. Appropriate analytical methods are developed to quantify them in different matrices.
- Are there alternatives to DEHP?
- MD manufacturers were therefore forced to quickly find alternatives to DEHP to maintain the elasticity of PVC nutrition tubings, infusion sets and hemodialysis lines. Several replacement plasticizers, so-called “alternative to DEHP plasticizers” were incorporated into the MDs.
- What methods are used to detect plasticizers?
- According to the literature, gas and liquid chromatographic methods with MS detection are the most widely employed techniques. These methods are suitable for the detection and quantification of plasticizer amounts over a broad range of values, depending on the media and the plasticizer .
