Blood Bag Plasticizers Influence Red Blood Cell Vesiculation
RBC mean cell volumes were greater in BTHC- than in DINCH- or DEHP-plasticized bags (p < 0.001). Osmotic fragility differed significantly among plasticizers (p < 0.01). After day 21, RBC deformability decreased in all, but to a greater extent in the bags with BTHC. Phospholipid composition of RBCs and EVs was not different among plasticizers.
Study-backs-options-for-blood-bag-plasticizers | Plastics News
Study backs options for blood bag plasticizers. Eastman partnered with the BloodCenter of Wisconsin to test Eastman 168 SG. Anaheim, Calif. — Eastman Chemical Co. conducted a clinical trial to
Searching for Alternative Plasticizers for Red Blood Cell
Currently, DEHP (di- (2-ethylhexyl) phthalate) is the “softener” used in blood bag production to provide the necessary durability and flexibility, as an example for red blood cell (RBC) storage. However, DEHP is known to leach out of the plastic blood bag into the RBC suspension and exposures to high levels of DEHP have been shown to cause
Non‐phthalate plasticizer DEHT preserves adequate blood
from whole blood (WB), platelets are in contact with the processing set plasticizer until preparation and may thus be affected. In this study, we focused on assessing the quality of RBCs produced and stored in PVC-DEHT blood bag sys-tems paired with SAGM or PAGGSM, during a 49-day storage period. The effects were compared to correspond-
DEHP plasticizer and blood bags: challenges ahead
apy that opened the door to blood component preparation and transfusion. Later, it was found that the plasticizer di-2-ethylhexyl-phthalate (DEHP) used in combi-nation with polyvinylchloride (PVC), leached to the blood component contained in the plastic bag and that in the case of the red blood cells, stabilized the mem-
- Can plasticizers replace DEHP in blood bags?
- Several plasticizers have been suggested as substitutes to DEHP in blood bags. Di(2-ethylhexyl) terephthalate (DEHT) and di-isononyl cyclohexane-1,2-dicarboxylic acid (DINCH) have shown the greatest potential so far, despite providing inferior RBC quality in previous studies [9 13].
- Are PVC-DEHT and PVC-DINCH blood bags safe for transfused patients?
- In addition to lower toxicity, transfused patients using PVC-DEHT or PVC-DINCH blood bags are less exposed to plasticizers than using PVC-DEHP bags with ranging exposure reduction from 38.9% to 87.3%, due to lower leachability into blood components. No impact of RBC storage solution on plasticizers migration.
- Do PVC blood bags plasticized with DEHT provide adequate red blood cell quality?
- As a future aspect, the individual contribution of different pro-duction parameters should be further explored. In conclusion, this study demonstrates that PVC blood bags plasticized with DEHT provide adequate red blood cell quality during 49 days of storage.
- What are the benefits of using a blood bag system?
- A blood bag system from Macopharma offers several benefits: 1. High quality break-away cannulas, which enable an optimized blood flow while maintaining blood component quality. 2. Outlet ports that provide sterility of blood components throughout the process. 3. Standard and numbered tubings are available on many systems, making sampling an essential step in your process easier.
- Is there a plasticizer substitute for RBCs?
- The lack of an acceptable plasticizer substitute for RBCs has slowed down the conversion process consid-erably, but recently, the demand became urgently moti-vated due to the updated European Commission regulation (EC) 2017/745 allowing a maximum concen-tration of 0 1% weight/weight of DEHP in medical devices .
- Which blood bags are made of PVC-DEHT / DEHP?
- Prototype blood bags made entirely of PVC-DEHT or PVC-DEHP, respectively (including tubes, ports and fil-ters), were manufactured for the study (Macopharma, Mouvaux, France), mimicking the commercially available quintuple bottom-and-top NPT reference (bag configura-tion: Supporting Information 1).
