Exposure to di(2-ethylhexyl) phthalate and diisononyl
Because of the wide production and use of DEHP, humans are exposed to DEHP on a daily basis. Diisononyl phthalate (DiNP) is often used as a DEHP replacement chemical, and because of the increased use of DiNP, humans are increasingly exposed to DiNP over time.
Promoting differentiation and lipid metabolism are the
Diisononyl phthalate (DINP) is a high-molecular-weight phthalate, and has been recently introduced as di- (2-ethyl hexyl) phthalate (DEHP) substitute and commonly used in a large variety of plastic items.
Foods | Free Full-Text | Endocrine-Disrupting Chemicals and
High-molecular-weight phthalates are di 2-ethylhexyl phthalate (DEHP), diisononyl phthalate (DiNP), diisodecyl phthalate (DiDP), and diisoundecyl phthalate (DiUP). Infant exposure can occur at the beginning of life via medical equipment for hospitalized babies, infant formulas, and breastfeeding [ 9 , 69 , 70 , 71 ].
Addition of Diisononyl Phthalate Category Proposed Rule
In August 2025, EPA issued a supplemental proposed rule to add a Di-isononyl phthalate (DINP) category to the list of toxic chemicals subject to the Toxics Release Inventory (TRI) reporting requirements under the Emergency Planning and Community Right-to-Know Act (EPCRA) and the Pollution Prevention Act (PPA).
Di-isononyl Phthalate (DINP); Final Scope of the Risk
Di-isononyl Phthalate (DINP) (1,2-Benzene- dicarboxylic acid, 1,2-diisononyl ester); Manufacturer Request for Risk Evaluation Under the Toxic Substances Control Act (TSCA); Notice of Availability and Request for Comments. Federal Register. ( 84 FR 42912, August 19, 2025) (FRL-9998-25). 2. EPA.
