Effect of different plasticizers on Eudragit RS100 and RL100
Eudragit RS100 and RL100 have shown good film forming property. As the thickness of film was increased, WVT rate decreased irrespective of plasticizers concentration. Therefore, 5% polymeric solutions were used for the sustained release coating. Table 2: Mechanical properties of free films of RS100 & RL 100 Formula no. Thickness (mm)
Effect of different plasticizers on Eudragit RS100 and RL100
The addition of plasticizers to a coating formulation generally increases the elongation and flexibility of the coating while reducing the tensile strength and elastic modulus. EUDRAGIT...
Comprehencive review on eudragit polymers - ResearchGate
One would always like to have an ideal polymer for controlled release of drug from particular dosage form that must possess the following two properties. 1) Polymer stability in acidic environment...
Effect of Different Plasticizers on Eudragit RS100 and RL100
Der Pharmacia Lettre Abstract Effect of Different Plasticizers on Eudragit RS100 and RL100 Free Film Author(s): Alpana J. Asnani and Virendra V. Parashar The physical properties of polymers used for modified-release coating of pharmaceutical dosage forms are governed by several variables such as plasticization, temperature and humidity.
Ocular Tolerability of Eudragit RS100 and RL100
Polymeric nanoparticle suspensions were prepared from inert polymer resins (Eudragit RS100, RS, and RL100, RL). When loaded with drugs, these resins have been recently proposed as delivery systems to prolong the release and improve ocular availability of the drug.
- Are RS and RL polymers nonadhesive materials?
- RS and RL polymers are considered nonadhesive materials; however, the positive charge present in these nanoparticles could account for a strong interaction with the negatively charged mucosa of the conjunctiva, thus allowing a sufficient residence time to permit an efficient drug release.
- Can RS and RL nanosuspensions improve ocular availability?
- When loaded with drugs, these resins have been recently proposed as delivery systems to prolong the release and improve ocular availability of the drug. To verify the absence of toxicity toward the ocular structures, blank RS and RL nanosuspensions were applied to rabbit eye and a modified Draize test was performed.
- How are RS and RL nanosuspensions prepared?
- RS and RL nanosuspensions were prepared by an opportunely adapted quasi-emulsion solvent diffusion method (QESD), initially described by Kawashima et al., 22,23 to achieve particles with suitable size, charge, and stability properties for their ophthalmic application.
