Phthalates impact human health: Epidemiological evidences and plausible
Diethylhexyl phthalate (DEHP) is the first phthalate introduced on this globe, which was in late 1920s; since its introduction as a plasticizer of PVC in 1931 [7], phthalates have been ramifying toward different domains including very sensitive cosmetics and perfumery industries; and its impact on the top consumers (humans) in the ecosystem is increasing accordingly in upward progression
Impact of DEHP plasticizer on human health back in play
Impact of DEHP plasticizer on human health back in play. A new preclinical study on DEHP led by a team at Children's National Health System (Washington, DC) finds that the plasticizer has “alarming . . . significant effects” on heart rhythm. A new preclinical study on DEHP plasticizer, commonly used to make PVC and other plastics pliable
Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview
DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo .
Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP)
Unfortunately, plasticizers can migrate within the material and leach out of it over time, ending up in the environment and, frequently, the human body. DEHP has come under increased scrutiny as its breakdown products are believed to be endocrine disruptors and more toxic than DEHP itself.
Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview - Hindawi
Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health.
- Are DEHP plasticizers a toxicity hazard?
- Exposure to DEHP plasticizers leads to toxicity in essential organs of the body through various mechanisms. The main objective of this review article is to focus on the DEHP-induced endoplasmic reticulum (ER) stress pathway implicated in the testis, brain, lungs, kidney, heart, liver, and other organs.
- Is DEHP harmful to children?
- The accumulation of the DEHP and the evidence of their toxic effects suggested that DEHP is having deleterious effects on human health and especially for the child who uses the plastic made toys and chews them (Posnack, 2014).
- Does DEHP exposure affect multiple organs in young and old mice?
- In this study, we initially compared the effects of DEHP exposure on multiple organs in young and old mice. We observed various damages, including changes in liver texture and cellular/histological morphology, spleen inflammation, renal inflammatory cell infiltration, and intestinal villus rupture.
- What is the pathophysiology of DEHP exposure in humans?
- The primary route of DEHP exposure in humans is contaminated food/water, additionally, exposure pathways, including inhalation and skin contact may also contribute to the estimated body burden of phthalates (Dutta et al., 2023).
- Do phthalates from recycled plastics affect human health?
- We found no reviews of epidemiological human studies on the impact of phthalates from recycled plastics on human health. We recommend that future research should use urine samples as exposure measures, consider confounders in analyses and measure impacts on female reproductive systems.
- How does DEHP affect the hippocampus?
- Intrauterine and lactational exposure to DEHP at low concentrations of 50 and 200 mg/kg/d decreased the levels of the N-methyl-d-aspartic acid (NMDA) receptor subunits NR1 and NR2B in the hippocampus in offspring mice, leading to impaired spatial learning and memory .
