Toxicity and molecular effects of di-n-butyl phthalate (DBP
The results showed that toxicity of DBP was intensified by increasing exposure time of DBP stress and responses of different tissues varied as a result of DBP metabolism. Besides, the gill was found to be a sensitive organ to DBP as a water pollutant.
Toxicity and molecular effects of di-n-butyl phthalate (DBP
Di-n-butyl phthalate (DBP), a widely used plasticizer in the plastic industry, affects regulation of the endocrine system and causes toxicity in animals.
Toxicity Review for Di-n-butyl Phthalate (Dibutyl Phthalate
The major metabolite for DBP is monobutyl phthalate (MBP). However, this metabolite is also considered one of the major metabolites for another phthalate, benzyl butyl phthalate (Ema, 1995). DBP’s potential risk to human health has been, and continues to be, investigated. Researchers have evaluated its developmental and reproductive effects
Dibutyl Phthalate - US EPA
The chemical formula for dibutyl phthalate is C 16 H 22 O 4, and the molecular weight is 278.35 g/mol. (1) The vapor pressure for dibutyl phthalate is 1.0 × 10-5 mm of Hg at 25 °C, and it has a log octanol/water partition coefficient (log K ow) of 5.60. (1) Dibutyl phthalate is also known as di-n-butyl phthalate. Conversion Factors:
Biomonitoring Summary | CDC
Dibutyl phthalates (both di-n-butyl and di-isobutyl phthalates, referred to as DBP) are industrial solvents or additives used in many personal care products such as nail polish and cosmetics, and also in some printing inks, pharmaceutical coatings, and insecticides.
- Does di-n-butyl phthalate cause germ cell toxicity?
- Provided by the Springer Nature SharedIt content-sharing initiative Di-n-butyl phthalate (DBP) is a kind of ubiquitous chemical linked to hormonal disruptions that affects male reproductive system. However, the mechanism of DBP-induced germ cells toxicity remains unclear.
- What is di-n-butyl phthalate (DBP)?
- Di-n-butyl phthalate (DBP), a well-known EDC, is widely used in industrial productions. The use or disposal of plastics leads to ubiquitous exposure to DBP, which adversely affects male reproductive health 2.
- Does di-n-butyl phthalate cause oxidative damage?
- Zhou, D. et al. Di-n-butyl phthalate (DBP) exposure induces oxidative damage in testes of adult rats. Syst. Biol. Reprod. Med. 56, 413–419 (2010). Qin, Z. et al. Protective effects of sulforaphane on di-n-butylphthalate-induced testicular oxidative stress injury in male mice offsprings via activating Nrf2/ARE pathway.
- Is di n -butyl phthalate a primary metabolite?
- No data were found on the concentration of the primary metabolite, mono- n -butyl phthalate, in human body tissues or fluids. 3.8.2. Biomarkers Used to Characterize Effects Caused by Di- n -butyl Phthalate Effects caused by di- n -butyl phthalate exposure in animals include liver changes and effects on development and reproduction.
- Does di n -butyl phthalate cause endocrine disruption?
- Studies in rats indicate that di- n -butyl phthalate has antiandrogenic properties (Ema et al. 1998, 2000b; Gray et al. 1999; Mylchreest et al. 1999, 2000). These are discussed in Section 3.6 Endocrine Disruption. Dermal Effects. No studies regarding dermal effects in humans or animals following oral exposure to di- n -butyl phthalate were located.
- Does di n -butyl phthalate cause cardiovascular toxicity?
- There is a limited amount of information available on the cardiovascular toxicity of di- n -butyl phthalate in humans. Hypertension was reported in workers exposed to di- n -butyl phthalate for 0.5–19 years at concentrations of 1.7–66 mg/m 3; the frequency increased with length of employment (Milkov et al. 1973).
