Plasticizer Enhancement on the Miscibility and

                                               
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Plasticizer Enhancement on the Miscibility and

                                               
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Enhancing Biopolymers: Additives Are Needed for Toughness

                                               
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Release Enhancement by Plasticizer Inclusion for Amorphous

                                               
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Polymers | Special Issue : Green Plasticizers for Polymers - MDPI

                                               
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  • Why are new plasticizers a problem?
  • The main problem in developing new plasticizers is to find a compound providing good mechanical properties to PVC, but with limited migration, extraction resistance and low volatility. There are a lot of studies describing novel plasticizers that exhibit excellent migration resistance at the expense of the deterioration of mechanical properties.
  • Do Plasticizers improve formulation performance and stability?
  • Although these plasticizers are effective as processing aid for HME, the effect of these plasticizers on formulation performance and stability is of utmost interest for the development of stabilized amorphous formulations. J. Swarbrick, J.C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology (19th ed.), Marcel Dekker Inc.,
  • Do plasticizers affect HME process and product performance?
  • Although various studies have demonstrated the effect of plasticizers on HME process and product performance, 21, 22, 23, 24, 25 no single study has investigated the systematic approach for selecting a suitable plasticizer.
  • Are plasticizers effective as processing aids for HME process?
  • The physical and mechanical properties of plasticizers, in selected binary (polymer:plasticizer) and ternary (active pharmaceutical ingredient:polymer:plasticizer) systems, were evaluated to assess their effectiveness as processing aids for HME process.
  • How does a plasticizer increase the free volume of a polymer?
  • The free volume can be understood as a gap between molecules and atoms in a temperature above the glass transition temperature with subtraction of the solid specific volume extrapolated to a particular temperature. The addition of a plasticizer increases the free volume, which implies increasing motion of polymer chains.
  • Are new plasticizers better than DOP?
  • The tensile strength and elongation at break studies showed no significant differences between new plasticizers and DOP. Besides, new plasticizers presented a lower viscosity than DOP, which is very important in PVC plastics production.