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Using this 4-step approach, we have identified 2 alternative chemicals displaying good plasticizing properties, better biodegradability, and less leaching than DEHP without any apparent toxicity in vivo. This process has thus far proven useful in the proactive identification of responsible chemical replacements for DEHP.

Using this 4-step approach, we have identified 2 alternative chemicals displaying good plasticizing properties, better biodegradability, and less leaching than DEHP without any apparent toxicity in vivo. This process has thus far proven useful in the proactive identification of responsible chemical replacements for DEHP. Keywords:

Consequently, there is increasing recognition by scientists, regulators and industry that proactive approaches are needed to develop safe chemical substitutes. We propose a 4-step approach for the design, characterization and toxicological testing of responsible alternative chemicals that we illustrate with our ongoing studies on DEHP replacements.

This work proposes a 4-step approach for the design, characterization and toxicological testing of responsible alternative chemicals that has thus far proven useful in the proactive identification of responsible chemical replacements for DEHP. The health and economic burden of endocrine disrupting chemicals, such as the plasticizer di(2-ethylhexyl) phthalate (DEHP), is prompting industry to

Identifying Greener and Safer Plasticizers: a Four-Step Approach. Toxicol Sci. 166:244. Albert O, Nardelli TC, Lalancette C, Hales BF, Robaire B. (2018) Effects of In Utero and Lactational Exposure to New Generation Green Plasticizers on Adult Male Rats: A Comparative Study With Di (2-Ethylhexyl) Phthalate. Toxicol Sci. 164:129.