Analysis of plasticizers in PVC medical devices: Performance
Performances of 8 methods to analyze plasticizers in medical devices have been compared. Each method has its analytical and environmental advantages and drawbacks. A blind test has been performed to confirm the results of the comparison study. This study provides advices and directions on the routine use of the methods. Abstract
Analysis of plasticizers in PVC medical devices: Performance
Analysis of plasticizers in PVC medical devices: Performance comparison of eight analytical methods Analysis of plasticizers in PVC medical devices: Performance comparison of eight analytical methods Authors
Analysis of plasticizers in PVC medical devices: Performance
Performances of 8 methods to analyze plasticizers in medical devices have been compared. Each method has its analytical and environmental advantages and drawbacks. A blind test has been performed to confirm the results of the comparison study. This study provides advices and directions on the routine use of the methods. Abstract
Analysis of plasticizers in PVC medical devices: Performance
Analytical method developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations. Expand 3 PDF
Analysis of plasticizers in PVC medical devices: Performance
Su uso en la industria médica se genera principalmente de PVC flexible dado a que posee gran cantidad de beneficios como estabilidad química, biocompatibilidad, claridad y transparencia,...
- How are plasticizers analyzed in PVC tubings?
- Chromatographic analyses of both the plasticizers in the PVC tubings after solvent extraction (before migration tests) and in the simulant after contact with the samples (specific migration) were performed according to the analytical method described by Bernard et al. (2015).
- Does plasticizer release a PVC MD into a simulant solution?
- We then tested the developed method on 32 PVC MDs used in our hospital and evaluated the plasticizer release from a PVC MD into a simulant solution during a 24 h migration test. The results showed a predominance of TOTM in PVC MDs accompanied by DEHP (<0.1% w/w), DEHT, and sometimes DEHA.
- How many plasticizers are found in medical devices analyzed?
- Distribution of the majority plasticizers in the 32 medical devices analyzed according to the type of MD. Moreover, in the MDs tested, trace levels of minority plasticizers are often found. Table 5 shows the quantities of the different plasticizers recovered from the MDs. Table 5. Plasticizer content of the 31 MDs analyzed.
- Can plasticizers be quantified in medical devices?
- For plasticizer quantification in MDs we chose to limit the sample quantity considering that the limit of quantification obtained on 10 mg was enough. Indeed we wanted to be able to analyze very small PVC samples from medical devices, so the less we used for extraction, the better. 3.4. Medical device tests
- What are the alternative plasticizers for PVC MDS?
- This resulted in the commercialization of PVC MDs plasticized with the DEHP alternative plasticizers tri-octyl trimellitate (TOTM), di- (2-ethylhexyl) terephthalate (DEHT), di-isononyl cyclohexane-1,2-dicarboxylate (DINCH), di-isononyl phthalate (DINP), di- (2-ethylhexy) adipate (DEHA), and Acetyl tri- n -butyl citrate (ATBC).
- Do plasticizers have a predominance of TOTM in PVC MDS?
- The results showed a predominance of TOTM in PVC MDs accompanied by DEHP (<0.1% w/w), DEHT, and sometimes DEHA. The migration tests showed a difference in the migration ability between the plasticizers and a non-linear kinetic release. 1. Introduction
