The Dopamine D5 receptor contributes to activation of
The D5 receptor belongs to the D1-type family of dopamine receptors that are coupled via Gα s /Gα olf and initiate cAMP/PKA signaling 10. Compared to the D1 receptor, in most regions of...
Immunomodulatory Effects of Dopamine in Inflammatory Diseases
Dopamine (DA) receptor, a significant G protein-coupled receptor, is classified into two families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further formation of homodimers, heteromers, and receptor mosaic. Increasing evidence suggests that the immune system can be affected by the nervous system and neurotransmitters, such as dopamine. Recently, the role of the
Mechanisms of D1/D2-like dopaminergic agonist, rotigotine, on
Rotigotine ( [-]2- (N-propyl-N-2-thienylethylamino)-5-hydroxytetraline) is a dopamine agonist with an affinity for all dopamine receptors (D1 to D5), which when delivered daily as a single...
Dopamine receptor D1- and D2-agonists do not spark brown
D1-like dopamine receptors (D1 and D5) are G s-coupled receptors and stimulate cAMP synthesis, whereas D2-like dopamine receptors (D2, D3, and D4) are G i-coupled and inhibit cAMP synthesis upon
Pharmacological blockade of dopamine D1- or D2-receptor in the
Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice. Disruption of the dopaminergic neuronal system in the PFC induced attentional impairment in the OBAT. However, previous studies have not systematically examined which
