Migration of plasticizers from PVC tubes into enteral
migration of plasticizers from the feeding equipment (sets) can lead to considerable amounts of plasticizer entering the patient’s body. This is because in general the transfer tubes and
Migration of plasticizers from PVC tubes into enteral
This hypothesis was supported by the findings of Welle et al. (2005) who reported high migration rates for ATBC from PVC tubes into enteral feeding solutions and food simulants.
Migrability of PVC plasticizers from medical devices into a
Available physicochemical data on the alternative plasticizers suggest a lesser migration from PVC compared to that of DEHP, mainly due to their higher molecular weights and the greater steric hindrance associated with less branching and/or lower water solubility ( Wilkes et al., 2005 ).
Migration of plasticizers from PVC medical devices
The manufacture of medical devices (MD), such as infusion or artificial nutrition tubings, from polyvinyl chloride (PVC) requires the incorporation of plasticizers, which are essential for the flexibility of the MD (Chiellini et al., 2013).
Migration of plasticizers from poly(vinyl chloride) and
Migration of plasticizers from poly(vinyl chloride) and multilayer infusion bags using selective extraction and GC-MS Flexible poly(vinyl chloride) (PVC) is widely used in the pharmaceutical industry for the manufacture of medical devices (tubes, probes, bags, primary packaging, etc.).
- Can inglobated plasticisers migrate from contact-approved PVC materials to food?
- In relation to food contact-approved PVC materials, inglobated plasticisers can gradually migrate from the plasticised object to foods depending on the influence of factors such as the temperature or the physical medium (solvent, food). The Regulation (EU) No. 10/2011 provides specific migration limits for different plasticisers.
- Do plasticizers migrate into food simulants?
- In addition, commercial films have been evaluated as to plasticizers concentration and specific migration into food simulants. It was found that 25% of the samples comply with the specific migration limits for fatty foods contact while 50% might be used for contact with fatty foods with FRF 2–5.
- How does a PVC film plasticizer move to a food simulant?
- The diffusion of the PVC film plasticizer to food or to food simulants occurs in two steps: within the polymer – migration takes place via diffusion process, usually according to Fick's Second Law, and in food or food simulant – the transport mechanism of the migrant depends on the physical properties of this phase.
- Does PVC film affect specific migration of plasticizers into aqueous acidic foods simulant?
- The samples of commercial PVC film displayed lower values of specific migration of plasticizers into aqueous acidic foods simulant than the quantification limit (LOQ) of the respective methods, even with concentration of approx. 40% in the formulation of the film ( Table 9 ).
- Why does plasticizing agent migrate from food contact PVC to packaged food?
- For this reason, the plasticizing agent can gradually migrate from food contact PVC surfaces into packaged foods in connection with concurring factors such as storage temperatures and/or the chemical and physical nature of the medium (solvent, food).
- Do plasticizers migrate into acidic foodstuffs?
- Thus, it has been demonstrated that a contact for prolonged time up to 40 °C did not promote the migration of plasticizers into acidic foodstuffs, but the migration of plasticizers to fatty foods can be high (75%–90% loss of plasticizers) and limit the use of PVC films as fatty food packaging. 1. Introduction
