Effect of glycerol plasticizer loading on the physical
Previous studies have documented that the film-forming properties of starch depend on the amylose content 44,45,46,47, strong and stiff films are made by linking linear chains by hydrogen bonding
[Effect of film formers and plasticizers on the stability
About 80% of commercial enteric coated drugs with coatings of celluloseacetate phthalate or polymethacrylic acid ester did not change acid resistance or disintegration time after 2 years, storage at 20 degrees C or 40 degrees C. Disintegration time of 4 drugs which are enteric coated with hydroxypropylmethylcellulose phthalate, decreased more
Effects of Polyol-Based Plasticizer Types and Concentration
The effectiveness of plasticizer depends on its molecular weight (Mw), polarity and durability [ 14, 35 ]. For most of the biopolymers water is an effective plasticizer but volatile. Furthermore, other non-volatile common plasticizers have been used for protein, biopolymer-based films.
The influence of different plasticizers on some
The tensile strength of plasticized HPMC films was generally lower than that of control HPMC film and could be attributed to increased crystallinity and segmental chain mobility of HPMC. This...
The plasticizer effect on preparation and properties
The introduction of plasticizers to the polymer matrix becomes necessary to improve the film properties. There are many reports about the addition of plasticizers at pure starch, due to their properties in decreasing films fragility, caused by higher intermolecular forces (Souza and Andrade, 2000, Zhang and Han, 2006).
- Do plasticizers affect polymeric coating properties?
- Various studies have been reported in the literature, investigating the effect of plasticizers on the properties of the final polymeric coating. Laboulfie et al. studied the effect of plasticizer on the mechanical resistance and thermal behavior of composite coating films.
- How does polymer-plasticizer incompatibility affect drug release?
- Polymer-plasticizer incompatibility influences not only the mechanical properties but also drug release , . Permanence of a plasticizer means its tendency to remain in the plasticized material; i.e. long term compatibility. It depends on the size of the molecule and on its rate of diffusion.
- Why is polymer-plasticizer incompatibility important?
- Compatibility between a polymer and a plasticizer produces stable and homogeneous coating film. It is often characterized by a high miscibility between the plasticizer and the polymer blend. Polymer-plasticizer incompatibility influences not only the mechanical properties but also drug release , .
- Do plasticized HPMC films increase tensile strength?
- The tensile strength of plasticized HPMC films was generally lower than that of control HPMC film and could be attributed to increased crystallinity and segmental chain mobility of HPMC. This effect increased as the concentration of plasticizer increased.
- Does polyethylene glycol (PEG) improve the mechanical properties of composite coating films?
- Laboulfie et al. studied the effect of plasticizer on the mechanical resistance and thermal behavior of composite coating films. They found that addition of a plasticizer (polyethylene glycol (PEG)) enhanced the plastic behavior of the HPMC-based coating films and improved its mechanical properties.
- What is a good plasticizer for HPMC films?
- Therefore, the increased crystallinity and the increase in films flexibility. triacetin were efficient as pl asticizers for HPMC films. For mechanical properties and moisture permeability resistance. as plasticizers. 7% HPMC (Pharmacoat 606) containing 10-30% PEG400. HPMC without additives.
