6. Do DIDP and DINP pose risks to human health? - GreenFacts
DIDP Workers For the dermal route, the worst case for external skin exposure is considered to occur when 5 mg/cm2 of pure DIDP is applied during 8 hours on a skin surface of 840 cm2 (for both hands), then, for worst-case situations, it is proposed to take a maximum dermal intake of 2.4 mg/day equivalent to 0.03 mg/kg/day for a 70-kg man.
6. Do DIDP and DINP pose risks to human health? - GreenFacts
Harmful effects to the liver and reproductive effects due to repeated exposure are considered to be the critical health effects in the risk assessment of DIDP and DINP. Risks are assessed by comparing worst case exposures to the exposures at which no harmful effects were observed in animal studies.
Committee for Risk Assessment (RAC) - Europa
result in RCRs exceeding 1 for all age groups for both DINP and DIDP (RCRs of 2.0 for 0-6 months, 1.6 for 6-12 months and 1.3 for 12-18 months respectively) based on DNELs of 0.075 mg/kg for both DINP and DIDP, which includes a modification of the dose descriptor of a factor 2. Combined exposure of the two phthalates based on reasonable worst case
Phthalate Di-isodecyl & Di-isononyl phthalates - SlideShare
Diisodecyl-phthalate (DIDP) and Diisononyl-phthalate (DINP) are two closely related substances that are mainly used as additives in plastics to make them more flexible. Their widespread use in everyday products, from floorings and shoe soles to toys has raised some concerns about their safety.
Risk Evaluation for Di-isodecyl phthalate (DIDP) (1,2-Benzene
EPA granted the manufacturer request for risk evaluation for di-isodecyl phthalate (DIDP) (1,2-Benzene- dicarboxylic acid, 1,2- diisodecyl ester) in December 2025, and this category of chemicals is currently undergoing risk evaluation. Learn more about manufacturer-requested risk evaluations.
- What are the critical health effects of DIDP & DINP?
- Harmful effects to the liver and reproductive effects due to repeated exposure are considered to be the critical health effects in the risk assessment of DIDP and DINP. Risks are assessed by comparing worst case exposures to the exposures at which no harmful effects were observed in animal studies.
- Are DINP/DIDP exposures a concern for workers?
- It is concluded that exposures to DINP or DIDP are of no concern for workers because they are well below the amounts that would cause harmful effects. The assessment concluded that there is at present no need for further information and/or testing or for further risk reduction measures beyond those being applied already. More...
- Does DIDP pose a risk to human health?
- Past assessments, including the CPSC’s risk assessment found that DIDP exposure comes primarily from diet for women, infants, toddlers, and children. It is possible that DIDP could pose risks to human health through uses or exposure pathways that are not regulated under TSCA.
- Does DIDP pose unreasonable risk to workers?
- In the draft risk evaluation for DIDP, EPA preliminarily determined that DIDP poses unreasonable risk of injury to human health to workers exposed to the chemical.
- How safe is DIDP & DINP?
- The environmental exposure assessment of DIDP and DINP has shown that the exposure of adults and infants via the environment is within the margins of safety when considering liver toxicity and developmental effects.
- Can EPA conduct a risk evaluation of DIDP & DINP?
- The risk evaluations of DIDP and DINP are the first two manufacturer-requested risk evaluations EPA has conducted. Under TSCA, manufacturers can request that EPA conduct risk evaluations on chemicals they manufacture. EPA received and granted manufacturer requests for risk evaluations of DIDP and DINP in 2019. DIDP
