Analysis of PVC plasticizers in medical devices and infused
Analysis of PVC plasticizers in medical devices and infused solutions by GC–MS - ScienceDirect Journal of Pharmaceutical and Biomedical Analysis Volume 118, 25 January 2016, Pages 206-213 Analysis of PVC plasticizers in medical devices and infused solutions by GC–MS Daniel Bourdeaux, Mouloud Yessaad, Chennell, Virginie Larbre, Eljezi, Bernard, ,
Analysis of PVC plasticizers in medical devices and infused
We then tested the developed method on 32 PVC MDs used in our hospital and evaluated the plasticizer release from a PVC MD into a simulant solution during a 24h migration test. The results showed a predominance of TOTM in PVC MDs accompanied by DEHP (
Analysis of PVC plasticizers in medical devices and infused
It is therefore important to know the abilities of these newly used plasticizers to migrate into the infused solutions that are directly in contact with the patients [5], [6], [7]. In order to evaluate patient exposure risk, plasticizer migration from medical devices must be assessed.
Analysis of plasticizers in PVC medical devices: Performance
Analysis of plasticizers in PVC medical devices: Performance comparison of eight analytical methods Analysis of plasticizers in PVC medical devices: Performance comparison of eight analytical methods Authors
Analysis of PVC plasticizers in medical devices and infused
Plasticizers Analysis of PVC plasticizers in medical devices and infused solutions by GC-MS DOI: 10.1016/j.jpba.2015.10.034 Authors: Daniel Bourdeaux Mouloud Yessaad Université Clermont...
- Are PVC plasticizers harmful to patients?
- The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evalu … Migrability of PVC plasticizers from medical devices into a simulant of infused solutions Int J Pharm.
- Are plasticizers in the PVC matrix a risk factor for patient exposure?
- The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evaluated the migration performance of DEHP, DEHT, DINCH, and TOTM using a model adapted to the clinical use of the MDs.
- How are plasticizers analyzed in PVC tubings?
- Chromatographic analyses of both the plasticizers in the PVC tubings after solvent extraction (before migration tests) and in the simulant after contact with the samples (specific migration) were performed according to the analytical method described by Bernard et al. (2015).
- Does plasticizer release a PVC MD into a simulant solution?
- We then tested the developed method on 32 PVC MDs used in our hospital and evaluated the plasticizer release from a PVC MD into a simulant solution during a 24 h migration test. The results showed a predominance of TOTM in PVC MDs accompanied by DEHP (<0.1% w/w), DEHT, and sometimes DEHA.
- Can plasticizers be quantified in medical devices?
- For plasticizer quantification in MDs we chose to limit the sample quantity considering that the limit of quantification obtained on 10 mg was enough. Indeed we wanted to be able to analyze very small PVC samples from medical devices, so the less we used for extraction, the better. 3.4. Medical device tests
- How many plasticizers are found in medical devices analyzed?
- Distribution of the majority plasticizers in the 32 medical devices analyzed according to the type of MD. Moreover, in the MDs tested, trace levels of minority plasticizers are often found. Table 5 shows the quantities of the different plasticizers recovered from the MDs. Table 5. Plasticizer content of the 31 MDs analyzed.
