Analytical methods for the determination of DEHP plasticizer
Analytical methods for the determination of DEHP plasticizer alternatives present in medical devices: a review Until 2010, diethylhexylphthalate (DEHP) was the plasticizer most commonly used to soften PVC medical devices (MDs), because of a good efficiency/cost ratio.
Analytical methods for the determination of DEHP plasticizer
Instead of reviewing all available analytical methods, this paper will focus on those suitable for the detection and quantification of the plasticizers in matrices, and which are appropriate for evaluating the patient exposure risk to the MDs plasticized PVC (i.e., the medical device itself, clinical conditions simulants, and human body fluids).
Simultaneous and sensitive determination of the main
With the prominent but toxicologically critical plasticizer di-(2-ethylhexyl) phthalate (DEHP) declining, alternative plasticizers are increasingly used leading to a continuously more diverse exposure situation of humans with multiple plasticizers. Therefore, an on-line SPE-LC-MS/MS method for the simultaneo
Simultaneous determination of polyvinylchloride plasticizers
To assess the migration of plasticizers from PVC medical devices into human blood we developed and validated an analytical method for the determination of DEHP and TOTM in combination with the determination of their primary degradation products mono (2-ethylhexyl) phthalate (MEHP), 1,2-di (2-ethylhexyl) trimellitate (1,2-DEHTM) and 2-mono
Simultaneous determination of polyvinylchloride plasticizers
Analytical determination was performed using tandem mass spectrometry with electrospray ionisation (Sciex API 2000, Applied Biosystems, Langen, Germany) coupled to a HPLC system model Agilent series 1100 (Agilent, Waldbronn, Germany) including a quaternary pump (Agilent G 1311A), a vacuum degasser (Agilent G 1322A) and an autosampler (Agilent G
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- How to analyze PVC plasticizer DEHP & TOTM in human blood?
- The developed analytical procedure enables the simultaneous determination of the common PVC plasticizer DEHP and its substitute TOTM in human blood using LC–MS/MS analysis following liquid–liquid extraction. At the same time, the degradation products MEHP, 2-MEHTM and 1,2-DEHTM can be determined.
- Are plasticizer DEHP and MEHP metabolites detectable in low concentrations?
- In contrast, the plasticizer DEHP as well as its metabolite MEHP were detectable in every sample in low concentrations with mean levels of 0.193 ± 0.078 mg/L and 0.004 ± 0.007 mg/L, respectively. The blank values were always taken into account by subtraction (cf. Section 2.5 ).
- Which plasticizer has a lower toxicity than DEHP?
- Since DEHP toxicity is an increasing matter of concern, there is a growing demand for alternative plasticizers , , like tri (2-ethylhexyl) trimellitate (TEHTM or TOTM). First results indicate that TOTM actually possesses a lower toxicity than DEHP , , , .
- Which method is used to identify plasticizers?
- Gas chromatography (GC) and liquid chromatography (LC) are the preferred indirect methods for the identification of plasticizers.
- Are there alternatives to DEHP?
- MD manufacturers were therefore forced to quickly find alternatives to DEHP to maintain the elasticity of PVC nutrition tubings, infusion sets and hemodialysis lines. Several replacement plasticizers, so-called “alternative to DEHP plasticizers” were incorporated into the MDs.
