Biological Effects of the Plasticizer Tris (2-Ethylhexyl
The effects of these plasticizers on human leukemia (HL)-60 viability and breast cancer cell MCF-7 proliferations were investigated. Furthermore, the affinity of these plasticizers for binding human estrogen receptor (ER)-α was measured using an enzyme-linked immunosorbent assay (ELISA) kit.
Biological Effects of the Plasticizer Tris (2-Ethylhexyl
The effects of these plasticizers on human leukemia (HL)-60 viability and breast cancer cell MCF-7 proliferations were investigated. Furthermore, the affinity of these plasticizers for...
iop Clinical Pharmacology Biopharmaceutics
Objectives: An alternative plasticizer, tris (2-ethylhexyl) trimellitate (TOTM), was developed from di-(2-ethylhexyl) phthalate (DEHP) for use in medical tubing. However, little is known about the biological effects of TOTM and thus its safety is not yet well-established.
Transcriptome profiling and pathway analysis of
In this study, we investigated toxicity effects of TOTM on hepatic differential gene expression analyzed by using high-throughput sequencing analysis for over-represented functions and phenotypically anchored to complementary histopathologic, and biochemical data in the liver of mice.
Metabolites of 4-methylbenzylidene camphor (4-MBC
The UV filter 4-methylbenzylidene camphor (4-MBC), used in cosmetics, the antioxidant butylated hydroxytoluene (BHT), used inter alia as a food additive and in cosmetics, and the plasticizer tris(2-ethylhexyl) trimellitate (TOTM), used mainly in medical devices as substitute for di-(2-ethylhexyl) phthalate (DEHP), are suspected to have
- Is tris 2 ethylhexyl trimellitate safe?
- Objectives: An alternative plasticizer, tris (2-ethylhexyl) trimellitate (TOTM), was developed from di- (2-ethylhexyl) phthalate (DEHP) for use in medical tubing. However, little is known about the biological effects of TOTM and thus its safety is not yet well-established.
- What is TRI-2 ethylhexyl trimellitate?
- National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. Tri-2-ethylhexyl trimellitate is a benzoate ester. tris (2-ethylhexyl) benzene-1,2,4-tricarboxylate
- How does Tris (2-ethylhexyl) trimellitate affect the environment?
- Tris (2-ethylhexyl) trimellitate's production and use as a plasticizer may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 3.8X10-6 mm Hg at 25 °C indicates tris (2-ethylhexyl) trimellitate will exist in both the vapor and particulate phases in the atmosphere.
- Does Tris (2-ethylhexyl) trimellitate cause subchronic toxicity?
- The subchronic toxicity of tris (2-ethylhexyl) trimellitate (TOTM) administered orally in the diet to groups of 5 male and 5 female Fischer 344 rats at levels of 0, 0.2, 0.67, 2.0% for 28 days was determined. There were no statistically significant differences in body weights between control and TOTM treated groups.
- How many workers are exposed to Tris (ethylhexyl) trimellitate?
- NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,023 workers (826 of these were female) were potentially exposed to tris (2-ethylhexyl) trimellitate in the US (1).
- Does Tris (2-ethylhexyl) trimellitate hydrolyze teht?
- There was no evidence for the hydrolysis of TEHT. The subchronic toxicity of tris (2-ethylhexyl) trimellitate (TOTM) administered orally in the diet to groups of 5 male and 5 female Fischer 344 rats at levels of 0, 0.2, 0.67, 2.0% for 28 days was determined.
