Biomonitoring Equivalents for di-isononyl phthalate (DINP)
Phthalate esters are the dialkyl or alkyl aryl esters of phthalic acid (also called 1,2-benzenedicarboxylic acid). For DINP, the alkyl chains range in length from C8 to C10, with various isomeric configurations. Therefore, DINP is not a single compound, but a complex mixture. There are two predominant DINP mixtures, based on the manufacturing
Biomonitoring equivalents for di-isononyl phthalate (DINP)
Biomonitoring Equivalents (BEs) are defined as the concentration or range of concentrations of a chemical or its metabolite in a biological medium (blood, urine, or other medium) that is consistent with an existing health-based exposure guideline such as a reference dose (RfD) or tolerable daily intake (TDI).
Diisononyl Phthalate (DINP) Reference List - US EPA
exposure to diisononyl phthalate (DINP) in children's product (80). U.S. Consumer Product Safety Commission. HERO ID: 791209, 9. Consumer Product Safety Commission. 2001. Report to the U.S. Consumer Product Safety Commission by the Chronic Hazard Advisory Panel on diisononyl phthalate (DINP) Bethesda, MD: U.S. Consumer Product Safety Commission.
Biomonitoring Summary | CDC
Di-isononyl phthalate (DiNP) is a mixture of phthalates with branched alkyl side chains of varying length (C8, C9, and C10). DiNP is primarily used to produce flexible plastics and has replaced di-2-ethylhexyl phthalate (DEHP) in some plastics, though not in medical products.
Human Exposure to Diisononyl Phthalate (DINP) - U.S. Consumer
To date, the majority of biomonitoring for DINP has consisted of analysis of human urine spot samples for metabolites of DINP. Initial efforts measured levels of the monoisononyl phthalate (MINP), the first metabolite of DINP, which is formed by cleaving one of the two alkyl chains from the benzenedicarboxylic acid moiety.
- What are high molecular-weight phthalates (DINP) and diisodecyl phthalate (D?
- High molecular-weight phthalates, such as diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP), are widely used as plasticizers in the manufacturing of polymers and consumer products. Human biological monitoring studies have employed the metabolites of DINP and DIDP as biomarkers to assess human exposure.
- Is the prevalence of human exposure to diisononyl phthalate (DINP) underestimated?
- The use of MINP as the sole biomarker for human exposure to diisononyl phthalate (DINP) is an underestimation. DINP is a complex mixture of branched-chain dialkyl phthalate isomers, predominantly containing nine carbons in the alkyl chain. Therefore, we concluded that the prevalence of human exposure to DINP is underestimated.
- Is Di (isononyl) phthalate mutagenic?
- According to McKee, Przygoda, Chirdon, Engelhardt, and Stanley (2000), Di (isononyl) phthalate (DINP) and di (isodecyl) phthalate (DIDP) are not mutagenic.
- What is diisononyl phthalate (DINP)?
- Diisononyl phthalate (DINP) is a complex mixture of predominantly nine-carbon branched-chain dialkyl phthalate isomers. It is analyzed as a metabolite in human urine (J Chromatogr B 805:161-167).
- Is MINP a metabolite of DINP?
- However, MONOISONONYL PHTHALATE (MINP) is only a minor urinary metabolite of DIISONONYL PHTHALATE (DINP). The major urinary metabolites in DINP-dosed rats include mono (carboxyisooctyl) phthalate (MCIOP), mono (oxoisononyl) phthalate (MOINP), and mono (hydroxyisononyl) phthalate (MHINP).
- Which phthalate is included in an NLM database?
- Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. High molecular-weight phthalates, such as diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP), are widely used as plasticizers in the manufacturing of polymers and consumer products.
