Doping in sport: What is it and how is it being tackled?

                                               
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Blood Doping Goes Back to the Future - The Atlantic

                                               
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'Blood Doping' Goes Back to the Future | RealClearScience

                                               
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Blood Doping and EPO: An Anti-Doping FAQ | USADA

                                               
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Doping in sports: is it worth it? - Medical News Today

                                               
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  • What happens if an athlete is doping?
  • The overall idea is that if an athlete is doping by means of blood transfusions, rhEpo injections or any other method with the purpose to increase red blood cell mass, this will lead to changes in a variety of haematological parameters such as reticulocyte count and [Hb].
  • How will blood doping affect erythropoietin synthesis?
  • Future blood doping practice will likely include the stabilization of the transcription factor hypoxia-inducible factor which leads to an increased endogenous erythropoietin synthesis. It seems unrealistic to develop specific test against such drugs (and the copies hereof originating from illegal laboratories).
  • How does blood doping affect athletic performance?
  • In many cases, blood doping increases the amount of hemoglobin in the bloodstream. Hemoglobin is an oxygen-carrying protein in the blood. So increasing hemoglobin allows higher amounts of oxygen to reach and fuel an athlete's muscles. This can improve stamina and performance, particularly in long-distance events, such as running and cycling.
  • What sports use blood doping?
  • Blood doping is used by athletes in a variety of endurance sports, including swimming, cycling, and skiing. Athletes in other sports may use plasma injections to speed physical recovery between competitions; some consider this a form of blood doping.
  • When should hematologists be familiar with blood doping practices?
  • Blood doping may be assumed, when these parameters change in a nonphysiologic way. Hematologists should be familiar with blood doping practices as they may play an important role in evaluating blood profiles of athletes with respect to manipulations, as contrasted with the established diagnosis of clinical disorders and genetic variations.
  • Do Athletes manipulate blood?
  • Confessions by athletes have revealed an ongoing yet extremely sophisticated modus operandi when manipulating the blood. In this review, weaknesses in detection methods and sample collection procedures are scrutinized and strategies developed to circumvent the test system discussed.