Guideline on the use of phthalates as excipients in human
Dibutyl phthalate (DBP) DBP was associated with an anti-androgenic effect in a human cell line as it inhibited the binding of dihydrotestosterone to the androgen receptor with an IC 50 of 74 M (Christen et al. 2010). DBP was devoid of oestrogenic activity in vitro (Lee et al. 2012).
Dibutyl phthalate
Dibutyl phthalate ( DBP) is an organic compound which is commonly used as a plasticizer because of its low toxicity and wide liquid range. With the chemical formula C 6 H 4 (CO 2 C 4 H 9) 2, it is a colorless oil, although commercial samples are often yellow. [3] Production and use [ edit]
DBP: 1. What are the properties of dibutyl phthalate (DBP)?
1. What are the properties of dibutyl phthalate (DBP)? DBP is an oily liquid that is soluble in fat and slightly soluble in water. It is not very volatile so does not vaporise readily into the atmosphere.
Di-n-butyl Phthalate (DBP) - Proposition 65 Warnings Website
Minimize exposure to dust, which can contain DBP: Wash your hands and your child’s hands frequently, especially before preparing food, and before eating. Clean floors regularly, using a wet mop or a vacuum cleaner with a high-efficiency particulate air (HEPA) filter, if possible. Wipe up dust regularly, using a damp cloth.
1 June 2009 Background document for dibutyl phthalate (DBP)
DBP is a specialist plasticiser often used in combination with other high molecular weight phthalates. It is also used as a gelling aid in combination with other plasticizers for nitrocellulose, cellulose ether, and polyacrylate and polyacetate dispersions.
- What is DBP (dibutyl phthalate)?
- DBP: Technical Data Sheet This technical data sheet provides information about dibutyl phthalate (DBP), including its chemical and physical properties, applications, and safety disclaimer. DBP is a colorless liquid with a slight aromatic odor that is used as a plasticizer to provide flexibility in adhesives, coatings, plastics, and rubber.
- Is DBP a low molecular weight phthalate?
- DBP is a low molecular weight phthalate and experimental determinations of water solubilities are believed to be reliable for lower molecular weight phthalates. For DBP, several aqueous solubility data are referred to in the literature ranging from 3.25 to 13.0 mg/l. The water solubility has been calculated to 1.53 mg/l /7/.
- What is the density and vapour pressure of DBP phthalate?
- The density is 1.042 g/ml and the vapour pressure is 2.7·10-5 mmHg at 25°C /1/. DBP is a low molecular weight phthalate and experimental determinations of water solubilities are believed to be reliable for lower molecular weight phthalates.
- What is DBP used for?
- It has a boiling point of 340°C, flash point of 171°C, and is soluble in substances like water, alcohol, ether, acetone and benzene. Common applications of DBP include as a plasticizer in PVA emulsions, solvent for dyes and chemicals, and to prevent foaming in some industries. DIBUTYL PTHALATE. DBP Structural Formula PROPERTIES
- What is monobutyl phthalate (MBP)?
- Monobutyl phthalate (MBP) is its major metabolite. Biodegradation by microorganisms represents one route for remediation of DBP. For example, Enterobacter species can biodegrade municipal solid waste—where the DBP concentration can be observed at 1500 ppm—with a half-life of 2–3 hours.
- Is dibutyl phthalate antimicrobial?
- Antimicrobial efficacy of dibutyl phthalate has been reported from Streptomyces . Dibutyl phthalate is also used as peroxisome proliferator, which is an effective compound against demodicidosis, as well as an endocrine disruptor with estrogenic activity, and a drug channeling agent.
