Guidance for Industry - Food and Drug Administration
exposure to dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP). In particular, the ... primarily as a plasticizer in enteric-coatings of solid oral drug products to maintain flexibility
Dibutyl phthalate
Dibutyl phthalate ( DBP) is an organic compound which is commonly used as a plasticizer because of its low toxicity and wide liquid range. With the chemical formula C 6 H 4 (CO 2 C 4 H 9) 2, it is a colorless oil, although commercial samples are often yellow. [3] Production and use [ edit]
Risk Evaluation for Dibutyl Phthalate (1,2-Benzene
Dibutyl phthalate (CASRN 84-74-2) is a colorless to faint yellow oily liquid. The primary use for dibutyl phthalate is as a plasticizer, in adhesives and sealants, and paints and coatings.
Guideline on the use of phthalates as excipients in human
Dibutyl phthalate (DBP) DBP was associated with an anti-androgenic effect in a human cell line as it inhibited the binding of dihydrotestosterone to the androgen receptor with an IC 50 of 74 M (Christen et al. 2010). DBP was devoid of oestrogenic activity in vitro (Lee et al. 2012).
DBP, Di Butyl Phthalates - Polymer Additives Selection
Polycizer DBP by Harwick Standard is a dibutyl phthalate-based plasticizer. It decreases milling time, increases plasticity and aids processing. It exhibits high-solvation and gives soft, flexible... view more Applications ABS Bioplastic>Cellulosic polymer Natural Rubber Other Rubber>CR, Chlorinated Rubber DBP KIC Chemicals
- What is di-butyl phthalate (DBP)?
- Di-Butyl Phthalate (DBP) is a versatile chemical compound widely used as a plasticizer in various industries. Its primary function is to improve the flexibility, durability, and workability of polymers such as polyvinyl chloride (PVC), cellulose-based plastics, resins, adhesives, and coatings.
- Why is di-butyl phthalate a good plasticizer?
- Its versatility and effectiveness as a plasticizer highlight its importance in modern manufacturing processes, contributing to the production of high-quality and functional products across multiple sectors. Di-Butyl Phthalate (DBP) is a versatile chemical compound widely used as a plasticizer in various industries.
- How is di-n-butyl phthalate (DBP) produced?
- DBP is produced by the reaction of phthalic anhydride with n-butanol in the presence of concentrated sulphuric acid as a catalyst. Excess alcohol is recovered and recycled and the di-n-butyl phthalate is purified by vacuum distillation and/or activated charcoal.
- How is dibutyl phthalate classified & labeled?
- The product is classified and labeled according to the Globally Harmonized System (GHS). GJ Chemical offers Dibutyl Phthalate (DBP), CAS# 84-74-2. Available in various grades, packaging and quantities from LTL to Bulk.
- What is DBP used for?
- DBP is an important plasticizer that enhances the utility of some major engineering plastics, such as PVC. Such modified PVC is widely used in plumbing for carrying sewage and other corrosive materials. Hydrolysis of DBP leads to phthalic acid and 1-butanol. Monobutyl phthalate (MBP) is its major metabolite.
- Is dibutyl phthalate a teratogen?
- Dibutyl phthalate (DBP) is one of the six phthalic acid esters found on the Priority Pollutant List, which consists of pollutants regulated by the United States Environmental Protection Agency (U.S. EPA). DBP was added to the California Proposition 65 (1986) list of suspected teratogens in November 2006.
