DEHP plasticizer and blood bags: challenges ahead - Lozano - 2013
The extraction of the plasticizer, DEHP, to the blood components contained in the DEHP-PVC bag provokes that not only the recipients of transfusions are exposed to significant levels of DEHP but also plasma and platelet apheresis donors are exposed.
DEHP plasticizer and blood bags: challenges ahead
the blood bags to be a drug), the acid-citrate-dextrose plastic blood bag system was nally approved by FDA in 1963, opening the era of blood component therapy [3]. A polyvinylchloride (PVC) copolymer plasticized with di-2-ethylhexyl-phthalate (DEHP) was chosen for their capacity to withstand sterilization by steam and yet be elastic and
DEHP plasticizer and blood bags: challenges ahead
Plasticizers are added during manufacture of blood bags to increase their flexibility and durability. There is also evidence that these plasticizers have the unexpected benefit of retarding...
DEHP plasticizer and blood bags: challenges ahead - Lozano - 2013
DEHP plasticizer and blood bags: challenges ahead M. Lozano J. Cid First published: 31 May 2013 https://doi.org/10.1111/voxs.12027 Citations: 9 2C‐S07‐01 Read the full text PDF Tools Share Abstract The invention of the plastic container represented a major advance in haemotherapy that opened the door to blood component preparation and transfusion.
Non-phthalate plasticizer DEHT preserves adequate blood
DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming regulatory restrictions for DEHP due to toxicity concerns increase the urgency to replace DEHP without compromising RBC quality.
- Can plasticizer DEHT replace DEHP in blood bags?
- Conclusion: Our study demonstrates that the plasticizer DEHT provides adequate blood component quality. We propose DEHT as a strong future candidate for replacement of DEHP in blood bags. Keywords: DEHP; DEHT; blood components; phthalates; plasticizers; red blood cells. © 2020 The Authors.
- Should DEHP be removed from blood bags?
- Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming regulatory restrictions for DEHP due to toxicity concerns increase the urgency to replace DEHP without compromising RBC quality. Di (2-ethylhexyl) terephthalate (DEHT) is one suggested substitute.
- Is DEHP a good storage option for red blood cells (RBC)?
- DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming regulatory restrictions for DEHP due to toxicity concerns increase the urgency to replace DEHP without compromising RBC quality.
- What is DEHP in PVC blood bags?
- In PVC blood bags, di- (2-ethylhexyl)phthalate (DEHP) has been used for more than 50 years as the plasticizer, resulting in a functional polymer with excellent characteristics such as inertness, flexibility, transparency, and high resistance to heat and chemicals.
- Do PVC bags contain DEHP?
- From the time of its introduction to the early 1980s, all PVC bags plastics contained the plasticizer DEHP. Although DEHP makes up about one third of the weight of the PVC bag and was known to be lipophilic, it was not until late 1960 that reports began to appear concerning the presence of DEHP in stored blood components.
- Does plasticizer DEHT provide adequate blood component quality?
- The metabolic parameters were not influenced by choice of plasticizer. Platelet activation/metabolism and plasma content were similarly preserved. Conclusion: Our study demonstrates that the plasticizer DEHT provides adequate blood component quality.
