Diverging trends of plasticizers (phthalates and non-phthalates)
Background European chemicals management aims to protect human health and the environment from legacy and emerging contaminants. The plasticizer market changed in response to the restriction of low molecular weight (LMW) phthalate plasticizers such as Di (2-ethylhexyl) phthalate (DEHP) due to their hazardous properties. We investigated patterns and trends of 19 regulated and emerging
Phthalates - ECHA - Europa
Phthalates Phthalates form a family of synthetic chemicals with a wide variety of uses, ranging from consumer to industrial products. There are different kind of phthalates and they are commonly used as softeners to make plastics, such as PVC, more flexible and durable.
DEHP vs. DINP as Plasticizer in PVC (Emerging Health hazard)
#1 DEHP leaching out from soft PVC in medical devices has been identified as a potential health hazard. On the same lines what is the call on DINP which is also used as plasticizer in PVC ? 1. Do they both have the same performance as plasticizers in PVC. 2. Is DINP identified as an emerging health hazard. 3. Can we substitute DEHP with DINP ?
Phthalates: European regulation, chemistry, pharmacokinetic and related
There are several types of phthalates, the following are the most common: DEHP, DINP, DIDP, BBP (Fig. 1). DEHP, also known as dioctyl phthalate (DOP), is produced by the chemical reaction of esterification between 2-ethyl-hexanol and phthalic anhydride. As in the case of other phthalates, DEHP is mainly used as a plasticizer in PVC products
Bis(2-ethylhexyl) phthalate
Bis (2-ethylhexyl) phthalate ( di-2-ethylhexyl phthalate, diethylhexyl phthalate, diisooctyl phthalate, DEHP; incorrectly — dioctyl phthalate, DIOP) is an organic compound with the formula C 6 H 4 (CO 2 C 8 H 17) 2. DEHP is the most common member of the class of phthalates, which are used as plasticizers. It is the diester of phthalic acid
- Are there alternatives to PVC plasticized with DEHP?
- Some alternatives may be suitable to replace DEHP in certain medical devices, while for other devices it may be difficult to obtain the same functionalities as PVC plasticized with DEHP. A risk assessment for the alternatives could not be performed due to a lack of exposure data.
- Are medical devices containing DEHP Plasticized PVC dangerous?
- In September 2002, the Scientific Committee on Medicinal Products and Medical Devices adopted an opinion on “Medical Devices containing DEHP plasticized PVC; Neonates and Other Groups Possibly at Risk from DEHP toxicity” according to which “there is no evidence that any of these groups do experience DEHP related adverse effects”.
- Is DEHP leaching out from soft PVC a health hazard?
- DEHP leaching out from soft PVC in medical devices has been identified as a potential health hazard. On the same lines what is the call on DINP which is also used as plasticizer in PVC ?
- 1. Do they both have the same performance as plasticizers in PVC. 2. Is DINP identified as an emerging health hazard. 3. Can we substitute DEHP with DINP ?
- Can bio-based plasticizers compete with DEHP in PVC?
- Potential alternatives to DEHP in PVC include diheptyl succinate (DHS), diethyl adipate (DEA), 1,4-butanediol dibenzoate (1,4-BDB), and dibutyl sebacate (DBS). To examine whether that these bio-based plasticizers can compete with DEHP, we need to compare their tensile, mechanical, and diffusional properties.
- How many DEHP molecules are there in a polyvinyl chloride (PVC) plasticizer?
- This system has 8 DEHP molecules, the diffusion of which are all tracked individually and then averaged to get the diffusion coefficients (red DEHP MSD line). Environmental and toxicity concerns dictate replacement of di (2-ethylhexyl) phthalate (DEHP) plasticizer used to impart flexibility and thermal stability to polyvinyl chloride (PVC).
- Is DINP a good alternative to DEHP?
- Therefore, DINP appears to be an alternative to most of the uses of DEHP (EU, 2008; www.dehp-facts.com), with the main exception for use in medical devices (European Council for Plasticisers and Intermediates, ECPI, 2007). About 95% of DINP is used in PVC applications.
