Analytical methods for the determination of DEHP plasticizer
Until 2010, diethylhexylphthalate (DEHP) was the plasticizer most commonly used to soften PVC medical devices (MDs), because of a good efficiency/cost ratio. In flexible plasticized PVC, phthalates are not chemically bound to PVC and they are released into the environment and thus may come into contact with patients.
Analytical methods for the determination of DEHP plasticizer
As plasticizers are not chemically bound to PVC, they can be released from the medical device during contact with blood, enteral or total parenteral nutrition admixtures, or lipophilic drugs, which might lead to unwanted patient exposure [2], [3], [4].
New SPE-LC-MS/MS method for the simultaneous determination
Plasticizers are considered as environmental pollution released from medical devices and increased potential oncogenic risks in clinical therapy. Our previous studies have shown that long-term exposure to di-ethylhexyl phthalate (DEHP)/mono-ethylhexyl phthalate (MEHP) promotes chemotherapeutic drug resistance in colorectal cancer.
Simultaneous determination of polyvinylchloride plasticizers
To assess the migration of plasticizers from PVC medical devices into human blood we developed and validated an analytical method for the determination of DEHP and TOTM in combination with the determination of their primary degradation products mono (2-ethylhexyl) phthalate (MEHP), 1,2-di (2-ethylhexyl) trimellitate (1,2-DEHTM) and 2-mono
[HPLC method to determine DEHP released into blood from a
We used blood as leaching medium, simulating clinical operation under maximum condition, to develop Liquid-phase extraction- High Performance Liquid Chromatography (HPLC) method for determination of plasticizer Di- (2-ethylhexyl)phthalate (DEHP) released from Disposable Extracorporeal Circulation Tube in order to lay the foundation of risk
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- How to analyze PVC plasticizer DEHP & TOTM in human blood?
- The developed analytical procedure enables the simultaneous determination of the common PVC plasticizer DEHP and its substitute TOTM in human blood using LC–MS/MS analysis following liquid–liquid extraction. At the same time, the degradation products MEHP, 2-MEHTM and 1,2-DEHTM can be determined.
- What is DEHP?
- DEHP, or diethylhexylphthalate, was the most commonly used plasticizer for softening PVC medical devices until 2010. It was favored for its good efficiency/cost ratio. However, in flexible plasticized PVC, phthalates like DEHP are not chemically bound to PVC and they are released into the environment, potentially coming into contact with patients.
- Why is DEHP a good plasticizer?
- For extracorporeal circulation circuits and blood transfusion sets, DEHP is the majority plasticizer. This can be explained by the supplier’s difficulty in replacing it without loss of functionality as well as by DEHP’s well-known stabilization effect on the red blood cells conserved in plastic bags .
- Does plasticizer release a PVC MD into a simulant solution?
- We then tested the developed method on 32 PVC MDs used in our hospital and evaluated the plasticizer release from a PVC MD into a simulant solution during a 24 h migration test. The results showed a predominance of TOTM in PVC MDs accompanied by DEHP (<0.1% w/w), DEHT, and sometimes DEHA.
- Which plasticizer has a lower toxicity than DEHP?
- Since DEHP toxicity is an increasing matter of concern, there is a growing demand for alternative plasticizers , , like tri (2-ethylhexyl) trimellitate (TEHTM or TOTM). First results indicate that TOTM actually possesses a lower toxicity than DEHP , , , .
