Determination of Plasticizers Commonly Used In Pharmaceutical
Two pharmaceutical applications of this assay included the quantitation of plasticizers in polymer-coated sugar beads and a leaching study of a water-soluble plasticizer, triethyl citrate,...
Determination of Plasticizers Commonly Used In Pharmaceutical
A simple reversed-phase HPLC method was developed to identify and quantify plasticizers commonly used with polymers present in sustained or controlled release dosage forms. the plasticizers investigated included triethyl citrate, tributyl citrate, acetyl triethyl citrate, dibutyl sebacate, diethyl phthalate, dibutyl phthalate, and triacetin. the
Determination of plasticizers commonly used in pharmaceutical
A simple reversed-phase HPLC method was developed to identify and quantify plasticizers commonly used with polymers present in sustained or controlled release dosage forms. the plasticizers investigated included triethyl citrate, tributyl citrate, acetyl triethyl citrate, dibutyl sebacate, diethyl phthalate, dibutyl phthalate, and triacetin. the plasticizers were detected at 220 nm, the mobile
Identification and quantification of plasticizers, bisphenol
In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) residues in sixteen medicines available in Tunisian pharmaceutical markets are evaluated by MSPD combined with GC-MS. In parallel, in this research, UPLC-MS/MS technique was performed to detect bisphenol A, and cadmium, lead, chromium, cobalt, nickel, mercury, selenium, and arsenic levels were determined by ICP-MS. The
Analytical & Pharmaceutical Research
A simple and efficient Gas Chromatography (GC) analysis method was developed to identify and quantify plasticizers commonly used with polymers present in delayed release tablets. The plasticizers investigated included Dibutyl Sebacate (DBS), Tributyl Phosphate (TBP) and Tributyl Acetyl Citrate (TBAC).
- Which method is used to identify plasticizers?
- Gas chromatography (GC) and liquid chromatography (LC) are the preferred indirect methods for the identification of plasticizers.
- How to identify alternative plasticizers?
- It is easy to obtain general information using very simple non-separative methods suitable for identifying the alternative plasticizers. These methods rely on the general features of polymers, like PVC and their plasticizers, such as thermolability and spectral and electromagnetic characteristics.
- Are plasticizers suitable for pharmaceutical applications?
- The extensive use of polymers in medical and pharmaceutical applications including particularly packaging, medical devices, drug carriers and coatings has caused a substantial demand for the proper plasticizers. Although there are many plasticizers used in the chemical industry, only a few of them have been approved for pharmaceutical applications.
- Which plasticizers can be used in a concentration range?
- The method developed by the authors can be applied to different types of plasticizers, like DINP or DEHP, within a concentration range of 10–50% by weight.
- What is the range of plasticizer concentrations in a polymer?
- The range of the concentrations of the plasticizer in the polymer is due to, besides other things, the crystallinity of the polymer, usually 5 % to 30 %, but there exist also deviations from this range. When plasticizers are present in low concentrations, their effect is often the exact opposite of what is typically expected.
- Which substances were used as plasticizers?
- Oily, waxy, or fatty substances were applied as plasticizers. Other invention relates to an oral pulse release comprising a polymer micromatrix, a first active ingredient distributed substantially uniformly within polymer micromatrix and a second active ingredient deposited on the surface of the polymer matrix (Gadre et al., 2006).
