Substance Information - ECHA - Europa
Di (2-ethylhexyl)phthalate Water Framework Directive, Annex X - Priority Substances, Annex I, Part A - Priority Substances & Pollutants in water Di (2-ethylhexyl)phthalate; DEHP IPPC - Industrial Emissions Directive, Annex II - Polluting Substances di- (2-ethylhexyl) phthalate C&L Inventory phthalic acid, bis (2-ethylhexyl) ester
Bis(2-ethylhexyl) phthalate
Di (2-ethylhexyl) phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It was first produced in commercial quantities in Japan around 1933 and in the United States in 1939. [7]
Dioctyl phthalate = 99.5 117-81-7 - Sigma-Aldrich
Bis (2-ethylhexyl) phthalate, DEHP, DOP, Phthalic acid bis (2-ethylhexyl ester) Linear Formula: C6H4-1,2- [CO2CH2CH (C2H5) (CH2)3CH3]2 CAS Number: 117-81-7 Molecular Weight: 390.56 Beilstein: 1890696 EC Number: 204-211-0 MDL number: MFCD00009493 PubChem Substance ID: 24893594 NACRES: NA.22 Pricing and availability is not currently available.
Phthalates: Uses, Safety Concerns, How to Read Labels - Verywell Health
Phthalates are used in soft plastic teethers and baby toys and can be hazardous to a baby’s health. Additionally, babies crawl around, touch many things, and put their hands in their mouths. 8. The Centers for Disease Control and Prevention (CDC) notes that phthalate particles are present in dust.
Phthalate
This includes Bis(2-ethylhexyl) phthalate (DEHP or DOP), which has long been the most widely used phthalate, with commercial production dating back to the 1930s. [27] [28] In the EU, the use of DEHP is restricted under REACH and it can only be used in specific cases if an authorisation has been granted; similar restrictions exist in many other jurisdictions.
- What is di-2-ethylhexyl phthalate (DEHP)?
- Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products.
- How is Di 2 ethylhexyl phthalate produced?
- Di (2-ethylhexyl) phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It was first produced in commercial quantities in Japan around 1933 and in the United States in 1939 (IARC, 1982).
- Is Di 2 ethylhexyl phthalate leached?
- Di (2-ethylhexyl) phthalate is leached in significant amounts from the PVC tubing used in transfusion and dialysis. Dialysis patients were studied for evidence of liver peroxisome proliferation in biopsy samples (Ganning et al., 1984, 1987).
- What are the effects of Di 2 ethylhexyl phthalate?
- Dietary levels of 0.1 and 0.3% di (2-ethylhexyl) phthalate produced dose-dependent and significant decreases in fertility and in the number and proportion of pups born alive. In males, 0.3% di (2-ethylhexyl) phthalate caused significantly reduced weights of the testes, epididymis, prostate and seminal vesicles.
- Is di (2-ethylhexyl) phthalate mutagenic?
- Two re-evaluations (Adler & Ashby, 1989; Ashby & Clapp, 1995) of these studies considered that cytotoxicity can interfere with the recognition of a dominant lethal effect, so that this reported mutagenic activity of di (2-ethylhexyl) phthalate is questionable. Di (2-ethylhexyl) phthalate did not induce changes in sperm morphology in mice or rats.
- How is Di 2 ethylhexyl phthalate metabolized in African green monkeys?
- In African green monkeys, di (2-ethylhexyl) phthalate was rapidly and extensively metabolized, with urinary excretion being 80% in the form of glucuronide conjugates (Albro et al., 1981, 1982). Peck and Albro (1982) also showed that di (2-ethylhexyl) phthalate was rapidly and extensively metabolized in both African green monkeys and humans.
