Subacute exposure to di-isononyl phthalate alters the
Di-isononyl phthalate (DiNP), a common plasticizer used in polyvinyl chloride products, exhibits endocrine-disrupting capabilities. It is also toxic to the brain, reproductive system, liver,...
Di-isononyl Phthalate (DINP) Impairs Reproduction
Phthalates such as DINP and DBP disrupted the ovarian and testicular steroidogenesis, altered the circulating levels of gonadal hormones and caused structural modifications in gonads...
The effects of the phthalate DiNP on reproduction - PubMed
Di-isononyl phthalate (DiNP) is a high molecular weight, general purpose, plasticizer used primarily in the manufacture of polymers and consumer products. It can be metabolized rapidly and does not bioaccumulate. The primary metabolite of DiNP is monoisononyl-phthalate (MiNP) and the secondary metab
Di-isononyl Phthalate (DINP) Impairs Reproduction in the
Reproductive toxicity of phthalate plasticisers in aquatic organisms is of major concern. Therefore, the present study was aimed to examine the role of di-isononyl phthalate (DINP) on...
EFFECTS OF PHTHALATE EXPOSURE ON THE GUT MICROBIOME
Toxicological Sciences (Chiu et al., 2025) Di-isononyl phthalate (DiNP) is a high-molecular-weight phthalate commonly used as a plasticizer for polyvinyl chloride and other end products, such as medical devices and construction materials. Most of our initial exposure to DiNP occurs by ingestion of DiNP-contaminated foods.
- Does exposure to DINP affect male reproduction?
- Occupational studies also indicate that the exposure to DiNP might induce negative effects on male reproduction, but larger cohort studies are needed to confirm this. This review presents an overview of the literature regarding the reproductive effects of exposure to DiNP.
- Does DINP cause reproductive toxicity?
- As the usage of DiNP worldwide increases, studies evaluating its potential reproductive toxicity are becoming more prevalent in the literature. In studies on female animals, the researchers found that the exposure to DiNP appears to induce negative effects on ovarian function and fertility in animal models.
- What is Di-isononyl phthalate (DINP)?
- Di-isononyl phthalate (DiNP) is a high molecular weight, general purpose, plasticizer used primarily in the manufacture of polymers and consumer products. It can be metabolized rapidly and does not bioaccumulate. The primary metabolite of DiNP is monoisononyl-phthalate (MiNP) and the secondary metab …
- Does DINP affect the uterus?
- In studies on female animals, the researchers found that the exposure to DiNP appears to induce negative effects on ovarian function and fertility in animal models. Whether or not DiNP has direct effects on the uterus is still controversial, and the effects on human reproduction require much more research.
- What are the metabolites of DINP?
- The primary metabolite of DiNP is monoisononyl-phthalate (MiNP) and the secondary metabolites include three oxidative derivatives of DiNP, which have been identified mainly in urine: mono-oxoisononyl phthalate (MOINP or oxo-MiNP), mono-carboxyisooctyl phthalate (MCIOP, MCOP or cx-MiNP), and mono-hydroxyisononyl phthalate (MHINP or OH-MiNP).
