Guidance for Industry - Food and Drug Administration
exposure to dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP). In particular, the guidance recommends that you, as part of the pharmaceutical industry, avoid the use of these two
Dibutyl phthalate
Dibutyl phthalate ( DBP) is an organic compound which is commonly used as a plasticizer because of its low toxicity and wide liquid range. With the chemical formula C 6 H 4 (CO 2 C 4 H 9) 2, it is a colorless oil, although commercial samples are often yellow. [3] Production and use [ edit]
Di-n-butyl Phthalate (DBP) - Proposition 65 Warnings Website
DBP can be absorbed into the body through contact with DBP-containing cosmetics household products and other products. DBP can be gradually released from consumer products into indoor environments such as homes, schools, daycare centers, and offices. During pregnancy, DBP can pass from mother to baby. How can I reduce my exposure to DBP?
Risk Evaluation for Dibutyl Phthalate (1,2-Benzene
Dibutyl phthalate (CASRN 84-74-2) is a colorless to faint yellow oily liquid. The primary use for dibutyl phthalate is as a plasticizer, in adhesives and sealants, and paints and coatings. Information from the 2016 Chemical Data Reporting (CDR) for dibutyl phthalate indicates the reported production volume is between 1 million and 10 million
Guideline on the use of phthalates as excipients in human
Dibutyl phthalate (DBP) DBP was associated with an anti-androgenic effect in a human cell line as it inhibited the binding of dihydrotestosterone to the androgen receptor with an IC 50 of 74 M (Christen et al. 2010). DBP was devoid of oestrogenic activity in vitro (Lee et al. 2012).
