Analysis of the impact of three phthalates on the freshwater

                                               
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Phthalate pollution: environmental fate and cumulative human exposure

                                               
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Hazards of diethyl phthalate (DEP) exposure: A systematic review

                                               
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Secondary oxidized di-2-ethylhexyl phthalate metabolites may be

                                               
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Distribution of phthalate esters in Egyptian edible oil - ResearchGate

                                               
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  • What is diethyl phthalate (DEP)?
  • Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of phthalates, but there is emerging evidence that DEP may be associated with other types of health effects.
  • Is diethyl phthalate soluble in water?
  • Diethyl Phthalate (DEP) is a commonly used chemical compound, primarily known for its use as a plasticizer. It is a colorless, odorless liquid that is soluble in various organic solvents but only slightly soluble in water. DEP is produced by the esterification of phthalic anhydride with ethanol.
  • Is diethyl phthalate a potent developmental toxicant?
  • DEP is not a potent developmental toxicant, although skeletal variations and decreased growth were observed. Low dose studies reported large magnitudes of effect but significant concerns for bias were identified. Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products.
  • What does diethyl phthalate taste like?
  • It is a colourless liquid without significant odour but with a bitter disagreeable taste. Diethyl phthalate is produced by the reaction of ethanol with phthalic anhydride, in the presence of a strong acid catalyst: It finds some use as a specialist plasticiser in PVC, it has also been used as a blender and fixative in perfume.
  • Does DEP cause phthalate syndrome?
  • Gestational exposure to DEP did not affect testosterone production or cause phthalate syndrome in rats. Effects of DEP on sperm may be consistent with the androgen-independent mode of action for phthalates. DEP is not a potent developmental toxicant, although skeletal variations and decreased growth were observed.
  • Does diethyl phthalate affect sexual differentiation?
  • However, diethyl phthalate does not alter sexual differentiation in male rats. Dose response experiments in fiddler crabs have shown that seven-day exposure to diethyl phthalate at 50 mg/L significantly inhibited the activity of chitobiase in the epidermis and hepatopancreas.