Hazards of diethyl phthalate (DEP) exposure: A systematic
Background. Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of phthalates, but there is emerging evidence that DEP may be associated with other types of health effects.
Analysis of the impact of three phthalates on the freshwater
This work analyzes the impact of three phthalates, diethyl phthalate (DEP), benzyl butyl phthalate (BBP), and bis-(2-ethylhexyl) phthalate (DEHP), on the gastropod Physella acuta at the molecular
Biomonitoring Summary | CDC
Diethyl phthalate (DEP) is a solvent used in many consumer products, particularly those containing fragrances. Products that may contain DEP include perfumes, colognes, deodorants, soaps, shampoos, and hand lotions. People exposed to DEP eliminate mono-ethyl phthalate (MEP) in their urine.
Hazards of diethyl phthalate (DEP) exposure: A systematic
Diethyl phthalate (DEP) is commonly used in personal care products and plasticizers with high levels of exposure in humans compared to other phthalates. This analysis of the data available in animals contributes to understanding potential health effects in humans. Description:
Guideline on the use of phthalates as excipients in human
on the impact of phthalate exposure are limited and therefore the clinical relevance of such findin gs remains to be established. The most commonly used phthalates in medicinal products licensed in the EU are: dibutyl phthalate (DBP), diethyl phthalate (DEP), polyvinyl acetate phthalate (PVAP), cellulose
- What is diethyl phthalate (DEP)?
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- ) Diethyl phthalate (DEP) is a phthalate ester. It is a colourless liquid without significant odour but with a bitter disagreeable taste. Diethyl phthalate is produced by the reaction of ethanol with phthalic anhydride, in the presence of a strong acid catalyst:
- What does diethyl phthalate taste like?
- It is a colourless liquid without significant odour but with a bitter disagreeable taste. Diethyl phthalate is produced by the reaction of ethanol with phthalic anhydride, in the presence of a strong acid catalyst: It finds some use as a specialist plasticiser in PVC, it has also been used as a blender and fixative in perfume.
- Is diethyl phthalate toxic?
- Little is known about the chronic toxicity of diethyl phthalate, but existing information suggests only a low toxic potential. Studies suggest that some phthalates affect male reproductive development via inhibition of androgen biosynthesis.
- Does diethyl phthalate affect sexual differentiation?
- However, diethyl phthalate does not alter sexual differentiation in male rats. Dose response experiments in fiddler crabs have shown that seven-day exposure to diethyl phthalate at 50 mg/L significantly inhibited the activity of chitobiase in the epidermis and hepatopancreas.
- Do phthalates affect male reproductive development?
- Studies suggest that some phthalates affect male reproductive development via inhibition of androgen biosynthesis. In rats, for instance, repeated administration of DEP results in loss of germ cell populations in the testis.
