Hazards of diethyl phthalate (DEP) exposure: A systematic review
Background. Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of phthalates, but there is emerging evidence that DEP may be associated with other types of health effects.
Analysis of the impact of three phthalates on the freshwater
This work analyzes the impact of three phthalates, diethyl phthalate (DEP), benzyl butyl phthalate (BBP), and bis-(2-ethylhexyl) phthalate (DEHP), on the gastropod Physella acuta at the molecular
Biomonitoring Summary | CDC
Diethyl Phthalate. CAS No. 84-66-2. General Information. Diethyl phthalate (DEP) is a solvent used in many consumer products, particularly those containing fragrances. Products that may contain DEP include perfumes, colognes, deodorants, soaps, shampoos, and hand lotions. People exposed to DEP eliminate mono-ethyl phthalate (MEP) in their urine.
Guideline on the use of phthalates as excipients in human medicinal
on the impact of phthalate exposure are limited and therefore the clinical relevance of such findin gs remains to be established. The most commonly used phthalates in medicinal products licensed in the EU are: dibutyl phthalate (DBP), diethyl phthalate (DEP), polyvinyl acetate phthalate (PVAP), cellulose
Registration Dossier - ECHA - Europa
Reference substance name: Diethyl phthalate EC Number: 201-550-6 EC Name: Diethyl phthalate CAS Number: 84-66-2 Molecular formula: C12H14O4 IUPAC Name:.
- What is diethyl phthalate (DEP)?
- Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of phthalates, but there is emerging evidence that DEP may be associated with other types of health effects.
- How is diethyl phthalate produced?
- Diethyl phthalate is produced by the reaction of phthalic anhydride with ethanol in the presence of sulfuric acid. ChEBI: The diethyl ester of benzene-1,2-dicarboxylic acid. Tetrahedron Letters, 34, p. 2629, 1993 DOI: 10.1016/S0040-4039 (00)77642-8
- Is diethyl phthalate soluble in water?
- Insoluble in water. Diethyl phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions.
- Is diethyl phthalate a potent developmental toxicant?
- DEP is not a potent developmental toxicant, although skeletal variations and decreased growth were observed. Low dose studies reported large magnitudes of effect but significant concerns for bias were identified. Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products.
- Does DEP cause phthalate syndrome?
- Gestational exposure to DEP did not affect testosterone production or cause phthalate syndrome in rats. Effects of DEP on sperm may be consistent with the androgen-independent mode of action for phthalates. DEP is not a potent developmental toxicant, although skeletal variations and decreased growth were observed.
- What does diethyl phthalate taste like?
- It is a colourless liquid without significant odour but with a bitter disagreeable taste. Diethyl phthalate is produced by the reaction of ethanol with phthalic anhydride, in the presence of a strong acid catalyst: It finds some use as a specialist plasticiser in PVC, it has also been used as a blender and fixative in perfume.
