Guideline on the use of phthalates as excipients in human
on the impact of phthalate exposure are limited and therefore the clinical relevance of such findin gs remains to be established. The most commonly used phthalates in medicinal products licensed in the EU are: dibutyl phthalate (DBP), diethyl phthalate (DEP), polyvinyl acetate phthalate (PVAP), cellulose
A comparative study on the impact of phthalate esters on soil
In this study, an isothermal microcalorimetric technique was used to demonstrate the impact of dimethyl phthalate (DMP), di-n-octyl phthalate (DOP) and diethyl phthalate (DEP) on soil microbial activity. The effect of these phthalate esters (≤100 μg g soil) follows the order: DEP > DMP > DOP
Phthalate Ester Concentrations, Sources, and Risks in the
Phthalate esters (PAEs) are excessively used in industries, which have posed a serious threat to human health. In this study, PAEs concentrations, sources, and risks in the ambient air of Tianjin, China were studied. The average concentrations of dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), butylbenzyl phthalate
Evaluation of the Removal of Selected Phthalic Acid Esters
The main aim of this study was the evaluation of the removal of six selected PAEs: diethyl phthalate (DEP), di- n -octyl phthalate (DOP), di- n -butyl phthalate (DBP), benzyl butyl phthalate (BBP), bis (2-ethylhexyl) phthalate (DEHP) and dimethyl phthalate (DMP), in real MWWTPs supported by constructed wetlands (MWWTP-CW system).
Diethyl phthalate and dioctyl phthalate in Plantago major L.
Diethyl phthalate, DEP (13.57) Dioctyl phthalate, DOP (54.15%) Figure 1. Mass spectra of diethyl phthalate (DEP) and 1, 2-Benzenedicarboxylic acid, diisooctyl ester (Di-n-octyl phthalate, DOP) in samples of P. major leaves widely distributed in the subtropics produces diethyl phthalate. The author suggests that diethyl phthalate and dioctyl
- What is diethyl phthalate (DEP)?
- Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of phthalates, but there is emerging evidence that DEP may be associated with other types of health effects.
- Is diethyl phthalate a potent developmental toxicant?
- DEP is not a potent developmental toxicant, although skeletal variations and decreased growth were observed. Low dose studies reported large magnitudes of effect but significant concerns for bias were identified. Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products.
- Does DEP cause phthalate syndrome?
- Gestational exposure to DEP did not affect testosterone production or cause phthalate syndrome in rats. Effects of DEP on sperm may be consistent with the androgen-independent mode of action for phthalates. DEP is not a potent developmental toxicant, although skeletal variations and decreased growth were observed.
- What are the risks of phthalates in microplastics?
- For human exposure, DEHP, DBP, and DiBP show high exposure risks. Phthalates in microplastics will continue to leach into the ocean. With global warming, the release of phthalates from microplastics will increase in nearshore environments with rising water temperatures. Phthalates are widely used as plasticizers in plastic production.
- How much phthalate (DEP) can a person eat a day?
- The no-observed-adverse-effect level for DEHP to humans is 4.8 mg/kg bodyweight/day and the tolerate daily intake (TDI) is 48 μg/kg bodyweight . Studies found that low molecular phthalates, such as DEP, can acutely irritate the skin, conjunctiva, and mucous membrane of the oral and nasal cavities .
- Does diethyl phthalate affect sexual differentiation?
- However, diethyl phthalate does not alter sexual differentiation in male rats. Dose response experiments in fiddler crabs have shown that seven-day exposure to diethyl phthalate at 50 mg/L significantly inhibited the activity of chitobiase in the epidermis and hepatopancreas.
